37772-86-4

Usage

Derivative of pyrrole

It is a chemical compound derived from pyrrole, which is a five-membered aromatic ring containing four carbon atoms and one nitrogen atom.

Used in organic synthesis and medicinal chemistry

1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-1-methyl-2-oxo-, ethyl ester is commonly used as a building block or intermediate in the synthesis of more complex organic molecules, including those with potential medicinal properties.

Potential pharmaceutical applications

1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-1-methyl-2-oxo-, ethyl ester has shown potential in the development of drugs for treating neurological disorders and cancer.

Acts as a precursor or intermediate

The compound serves as a starting material or intermediate in the synthesis of various bioactive molecules, which can have therapeutic effects.

Ethyl ester form

The ethyl ester functional group is present in the compound, which allows for easy handling and manipulation in laboratory settings.

Interaction with cellular receptors and enzymes

Studies have shown that 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-1-methyl-2-oxo-, ethyl ester can interact with specific cellular receptors and enzymes, which may contribute to its potential therapeutic effects in neurological disorders and cancer treatment.

Upstream product

• 107-97-1 sarcosine 
• 105-53-3 diethyl malonate 
• 1071-46-1 hydrogen ethyl malonate 
• 651739-87-6 ethyl 4-[(tert-butoxycarbonyl)(methyl)amino]-2-(ethoxycarbonyl)-3-hydroxy-2-butenoate 

Relevant academic research and scientific papers

Cyclisation of Novel Amino Oxo Esters to Tetramic Acids - Density Functional Theory Study of the Reaction Mechanism

The synthesis of novel N-urethane-protected γ-methylanlino-β -oxo esters and their use as precursors for the preparation of N-methyltetramic acids is described. The presence of the bulky urethane protecting group on the nitrogen atom gives rise to rotational isomers detectable in the NMR spectra of the compounds, along with the keto/enol tautomerism. The mechanism of the cyclisation reaction of γ-amino-β-oxo esters to tetramic acids was studied theoretically by the B3LYP hybrid density functional method. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

A traceless solid-phase approach to functionalized tetramic acids and 2-amino-4-pyrrolinones

A novel traceless route for the synthesis of optically active functionalized tetramic acids and 2-amino-4-pyrrolinones on solid support is described. p-Nitrophenyl carbonate linker on Wang resin is used to anchor L-α-Amino acids by their N-terminus thus leaving the carboxylic function free for further elaboration. High yields and ee, in combination with the versatility implied by the wide range of commercially available building blocks, are the major advantages of the proposed methodology. Georg Thieme Verlag Stuttgart.

Simple route to azabicyclic peroxides from tetramic acid derivatives using manganese(III)-based molecular oxygen trapping reaction

A simple one-step synthesis of azabicyclic peroxides was achieved by the manganese(III)-mediated oxidative formal [2+2+2] cycloaddition. The reaction of alkenes (1) with pyrrolidinediones (2) was carried out with manganese(III) acetate in acetic acid at 2