377731-29-8Relevant articles and documents
Kinase inhibitors (by machine translation)
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Paragraph 0372-0373, (2020/12/31)
The present invention relates to certain 4 - (substituted anilino) -2 - (substituted piperi -1 -yl) pyrimidine -5 - carboxamide compounds useful for the treatment or prevention of diseases or medical conditions mediated by signal transduction of CaMMK1 isotype. For example, such compounds and salts thereof may be used to treat or prevent a variety of different cancers. Diseases (including 2 diabetes) and/or immune-mediated diseases. (by machine translation)
SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS
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Page/Page column 59, (2010/11/03)
Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.
HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS
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Page/Page column 163-164, (2010/11/30)
The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cyt
BISAMIDE CYTOKINE INHIBITORS
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Page/Page column 110, (2008/06/13)
The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are bisamides and are useful as anti-inflammatory agents. In one aspect the compounds have the
HETEROCYCLIC CYTOKINE INHIBITORS
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Page/Page column 136, (2010/11/27)
The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory, anti-pain or anti-cancer agents. There are further provided m
Reversible formation of a [2]catenane through first- and second-sphere coordination
Blight, Barry A.,Wisner, James A.,Jennings, Michael C.
, p. 2835 - 2838 (2008/02/11)
(Figure Presented) Reversible catenation: A remarkably stable [2]catenane (see picture; Pd turquoise, Cl green) is formed in one step through a combination of first- and second-sphere coordination of a bidentate ligand and the {PdCl2} metal cen
Cyclic derivatives as modulators of chemokine receptor activity
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Page/Page column 45, (2008/06/13)
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the treatment of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma.
Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
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Page/Page column 44, (2010/02/11)
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.
Naaladase inhibitors for treating retinal disorders and glaucoma
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, (2008/06/13)
The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.
Thiol-based NAALADase inhibitors
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, (2008/06/13)
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effect
