37787-62-5

Upstream product

• 37787-61-4 (6R)-3-methylene-5c,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid methyl ester 
• 186581-53-3 diazomethane 
• 27508-30-1 (5R,6R,7R)-3-Methyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 89753-46-8 benzhydryl-7-amino-3-methyl-3-cephem-4-carboxylate 1R-(α)-oxide 
• 701-99-5 Phenoxyacetyl chloride 
• 22252-43-3 3-deacetyloxy-7-aminocephalosporanic acid 
• 37850-81-0 7β-salicylideneamino-3-methyl-3-cephem-4-carboxylic acid 
• 52210-39-6 7β-salicylideneamino-3-methyl-3-cephem-4-carboxylic acid 1R-(α)-oxide 
• 40849-60-3 7-Phenoxyacetamido-3-exo-methylene cepham 
• 37787-58-9 (6R)-3-methylene-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid methyl ester 

Downstream Products

• 52725-89-0 methyl 7-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 

Relevant academic research and scientific papers

SYNTHESIS AND 1,3-DIPOLAR CYCLOADDITIONS OF 2-METHYLENECEPHALOSPORINS

Cephalosporin R- and S-sulphoxides were prepared.The S-sulphoxides gave Mannich-reaction resulting in the formation of 2-methylenecephalosporins.These electrom-deficient dienes underwent 1,3-dipolar cycloadditions with diazoalkanes in a chemo- and regiosp