37795-81-6

Basic information

• Product Name: 6-chloro-2,3-dihydro-9H-[1,2]oxazolo[3,2-b]quinazolin-9-one
• Synonyms: 9H-Isoxazolo(3,2-b)quinazolin-9-one, 6-chloro-2,3-dihydro-; 9H-Isoxazolo[3,2-b]quinazolin-9-one, 6-chloro-2,3-dihydro-
• CAS NO: 37795-81-6
• Molecular Formula: C₁₀H₇ClN₂O₂
• Molecular Weight: 222.6278
• Mol File: 37795-81-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 378°C at 760 mmHg
• Flash Point: 182.4°C
• Density: 1.62g/cm³
• Vapor Pressure: 6.47E-06mmHg at 25°C
• Refractive Index: 1.735
• CAS DataBase Reference: 6-chloro-2,3-dihydro-9H-[1,2]oxazolo[3,2-b]quinazolin-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2,3-dihydro-9H-[1,2]oxazolo[3,2-b]quinazolin-9-one(37795-81-6)
• EPA Substance Registry System: 6-chloro-2,3-dihydro-9H-[1,2]oxazolo[3,2-b]quinazolin-9-one(37795-81-6)

Safety Data

• Hazardous Substances Data: 37795-81-6(Hazardous Substances Data)

Upstream product

• 1192-07-0 isoxazolidin-3-one 
• 40928-13-0 4-chloroisatoic anhydride 

Relevant articles and documents

2,3 Dihydro 9H isoxazolo[3,2 b]quinazolin 9 ones and 3,4 dihydro (1,2) oxazino[3,2 b]quinazolin 10(2H) ones

Two series of compounds, 2,3-dihydro-9H-isoxazolo [3,2-b] quinazolin-9-ones and 3,4-dihydro-(1,2)-oxazino-[3,2-b]quinazolin-10 (2H)-ones, were synthesized and evaluated for anti-inflammatory, antipyretic and analgesic activity. The isoxazolo compounds were generally more active than their oxazino homologs. Three compounds, i.e., 2,3-dihydro 9H isoxazolo [3,2-b]quinazolin-9-one (W-2429) and its 2- and 3-methyl congeners, were the most active of all compounds tested in this study. On the basis of the biological results herein reported, W-2429 is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats. Also, it was found to be more potent than propoxyphene hydrochloride in the Randall-Selitto test for analgesic activity.