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1192-07-0

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1192-07-0 Usage

General Description

ISOXAZOLIDIN-3-ONE, also known as isoxazolidine-3-one, is a heterocyclic organic compound that contains both a nitrogen and an oxygen atom in its five-membered ring structure. It is commonly used in organic synthesis as a versatile building block for the preparation of various pharmaceuticals, agrochemicals, and bioactive compounds. ISOXAZOLIDIN-3-ONE is known for its high reactivity and ability to undergo various chemical transformations, making it a valuable intermediate in the production of diverse chemical products. It has also been studied for its potential biological and pharmacological activities, including its antimicrobial, antifungal, and antitumor properties, making it a promising target for drug discovery and development. Overall, ISOXAZOLIDIN-3-ONE plays a crucial role in the field of organic chemistry and has a wide range of potential applications in various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 1192-07-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 2 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1192-07:
(6*1)+(5*1)+(4*9)+(3*2)+(2*0)+(1*7)=60
60 % 10 = 0
So 1192-07-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H5NO2/c5-3-1-2-6-4-3/h1-2H2,(H,4,5)

1192-07-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Isoxazolidin-3-one

1.2 Other means of identification

Product number -
Other names 1,2-oxazolidin-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1192-07-0 SDS

1192-07-0Relevant articles and documents

Synthesis and in vitro pharmacology of novel heterocyclic muscarinic ligands

De Amici, Marco,Conti, Paola,Fasoli, Ezio,Barocelli, Elisabetta,Ballabeni, Vigilio,Bertoni, Simona,Impicciatore, Mariannina,Roth, Bryan L.,Ernsberger, Paul,De Micheli, Carlo

, p. 739 - 748 (2003)

A set of novel heterocyclic ligands (7a-9a, 7b-9b, and 9c) structurally related to oxotremorine 2 was designed, synthesized, and tested at muscarinic receptor subtypes. In the binding experiments at cloned hm1-5, the presence of the 2-methylimidazole/2-me

3-ISOXAZOLIDONE FROM JACK BEAN SEEDLINGS

Sugii, Michiyasu,Miura, Hiroshi,Nagata, Kazutoshi

, p. 451 - 454 (1981)

Key Word Index - Canavalia ensiformis; Leguminosae; jack bean; 3-isoxazolidone; L-canavanine; L-canaline; pentacyanoammoniferrate reagent; Jaffe reagent. 3-Isoxazolidone has been isolated from jack bean seedlings.

3-Aminoxypropionate-based linker system for cyclization activation in prodrug design

Ge, Yiyu,Wu, Xinghua,Zhang, Dazhi,Hu, Longqin

scheme or table, p. 941 - 944 (2009/08/15)

A novel linker system based on 3-aminoxypropionate was designed and evaluated for drug release using proteolysis as an activation trigger followed by intramolecular cyclization. The hydroxylamine moiety present in the linker system enabled faster release of the parent drug from the linker-drug conjugate at lower pH as compared to an aliphatic amine moiety. Introduction of two methyl groups strategically at the α position to the carboxylate in the linker further improved the rate of cyclization by nearly 2-fold. The 3-aminoxypropionate linker was successfully applied to a model prodrug for protease activation using α-chymotrypsin as the activating enzyme; the activation of the model prodrug bearing the 3-aminoxypropionate linker was 136 times faster than the corresponding model prodrug bearing an amine linker.

Cyclic hydroxamates, especially multiply substituted [1,2]oxazinan-3-ones

Wolfe, Saul,Wilson, Marie-Claire,Cheng, Ming-Huei,Shustov, Gennady V.,Akuche, Christiana I.

, p. 937 - 960 (2007/10/03)

Routes to putative N-acyl-D-ala-D-ala surrogates, beginning with the conversion of 4-, 5-, and 6-membered lactones into 5-, 6-, and 7-membered cyclic hydroxamates, are reported. The key step of the synthesis is trimethylaluminium-promoted cyclization of an ω-aminooxyester. The 7-membered cyclic hydroxamate crystallizes in a chair conformation. Extension of the reaction sequence to homoserine or homoserine lactone leads to cyclocanaline and N-acylated cyclocanalines. The 4-phenylacetamido derivative of cyclocanaline crystallizes in a boat conformation. The attachment of a 2-carboxypropyl substituent to the ring nitrogen of a 4-acylaminocyclocanaline has been effected, prior to cyclization, by coupling of the acyclic aminooxyester precursor to the triflate of benzyl lactate or, after cyclization, by coupling to tert-butyl α-bromopropionate in the presence of potassium fluoride - alumina, followed by removal of the protecting group in each case. A six-membered homolog of the antibiotic lactivicin has been synthesized by the reaction of 4-phenylacetamidocyclocanaline with benzyl 2-oxoglutarate in the presence of carbodiimide, followed by hydrogenolysis. Starting with methyl 2,4-dibromo-2,4-dideoxy-L-erythronate, which is available in two steps from L-ascorbic acid, these reaction sequences have been applied to the stereospecific synthesis of a D-alanine derivative whose nitrogen atom is enclosed within a 3,4-disubstituted [1,2]oxazinan-3-one.

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