378185-87-6

Upstream product

• 332186-72-8 Methyl 3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)propanoate 
• 332186-71-7 Methyl (E)-3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)-2-propenoate 
• 332186-70-6 4-Iodo-3,5-dimethyl-O-tert-butoxycarbonylphenol 
• 263239-05-0 3-(4-tert-Butoxycarbonyloxy-2,6-dimethylphenyl)propanoic acid 
• 108-68-9 3,5-Dimethylphenol 
• 80826-86-4 4-iodo-3,5-dimethylphenol 
• 1521-51-3 rac-3-bromocyclohexene 
• 332186-73-9 (4S)-4-Benzyl-3-[3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)propanoyl]-1,3-oxazolan-2-one 

Relevant academic research and scientific papers

Stereospecific syntheses of 2-alkyl and 2-phenyl substituted 3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acids

Stereospecific syntheses of 2-methyl-, 2-ethyl-, 2-cyclohexyland 2-phenyl- substituted 3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acids were developed. The key steps for the formation of the stereogenic centers involved the utilization of Evans' 4-benzyl-2-oxazolidinone chiral auxiliary. These compounds were designed to replace the N-terminal tyrosine residue in opioid peptides.