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3782-83-0

4-(4-Ethoxycarbonyl-phenyliminomethyl)-diphenylether is a complex organic compound with the molecular formula C21H19NO3. It is characterized by a diphenylether core, which consists of two phenyl rings connected via an oxygen atom. One of the phenyl rings is substituted with an ethoxycarbonyl group (-COOCH2CH3), and the other is connected to an iminomethyl group (-CH=N-). This iminomethyl group is further attached to a 4-ethoxycarbonyl-phenyl moiety, creating a unique structure. 4-(4-Ethoxycarbonyl-phenyliminomethyl)-diphenylether is of interest in organic chemistry and may have potential applications in the synthesis of pharmaceuticals or other specialty chemicals due to its specific functional groups and structural features.

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  • 3782-83-0 Structure

  • Basic information

    1. Product Name: 4-(4-Ethoxycarbonyl-phenyliminomethyl)-diphenylether
    2. Synonyms: 4-(4-Ethoxycarbonyl-phenyliminomethyl)-diphenylether
    3. CAS NO:3782-83-0
    4. Molecular Formula:
    5. Molecular Weight: 345.398
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 3782-83-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(4-Ethoxycarbonyl-phenyliminomethyl)-diphenylether(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(4-Ethoxycarbonyl-phenyliminomethyl)-diphenylether(3782-83-0)
    11. EPA Substance Registry System: 4-(4-Ethoxycarbonyl-phenyliminomethyl)-diphenylether(3782-83-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3782-83-0(Hazardous Substances Data)

3782-83-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3782-83-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,8 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3782-83:
(6*3)+(5*7)+(4*8)+(3*2)+(2*8)+(1*3)=110
110 % 10 = 0
So 3782-83-0 is a valid CAS Registry Number.

3782-83-0Relevant articles and documents

Discovery of liver selective non-steroidal glucocorticoid receptor antagonist as novel antidiabetic agents

Shah, Kiran,Patel, Dipam,Jadav, Pradip,Sheikh, Mubeen,Sairam, Kalapatapu V. V. M.,Joharapurkar, Amit,Jain, Mukul R.,Bahekar, Rajesh

, p. 5857 - 5862,6 (2012)

Series of benzyl-phenoxybenzyl amino-phenyl acid derivatives (8a-q) are reported as non-steroidal GR antagonist. Compound 8g showed excellent h-GR binding and potent antagonistic activity (in vitro). The lead compound 8g exhibited significant oral antidia

Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation

Cheung, Sun-Yee,Werner, Markus,Esposito, Lucia,Troisi, Fabiana,Cantone, Vincenza,Liening, Stefanie,K?nig, Stefanie,Gerstmeier, Jana,Koeberle, Andreas,Bilancia, Rossella,Rizza, Roberta,Rossi, Antonietta,Roviezzo, Fiorentina,Temml, Veronika,Schuster, Daniela,Stuppner, Hermann,Schubert-Zsilavecz, Manfred,Werz, Oliver,Hanke, Thomas,Pace, Simona

supporting information, p. 815 - 830 (2018/07/29)

Leukotrienes (LTs) and prostaglandin (PG)E2, produced by 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1), respectively, are key players in inflammation, and pharmacological suppression of these lipid mediators (LM) represents a strategy to intervene with inflammatory disorders. Previous studies revealed that the benzenesulfonamide scaffold displays efficient 5-LO-inhibitory properties. Here, we structurally optimized benzenesulfonamides which led to an N-phenylbenzenesulfonamide derivative (compound 47) with potent inhibitory activities (IC50 = 2.3 and 0.4 μM for isolated 5-LO and 5-LO in intact cells, respectively). Compound 47 prevented the interaction of 5-LO with its activating protein (FLAP) at the nuclear envelope in transfected HEK293 cells as shown by in situ proximity ligation assay. Comprehensive assessment of the LM profile produced by human macrophages revealed the ability of 47 to selectively down-regulate pro-inflammatory LMs (i.e. LTs and PGE2) in M1 but to enhance the formation of pro-resolving LMs (i.e. resolvins and maresins) in M2 macrophages. Moreover, 47 strongly inhibited LT formation and cell infiltration in two in vivo models of acute inflammation (i.e., peritonitis and air pouch sterile inflammation in mice). Together, 47 represents a novel LT biosynthesis inhibitor with an attractive pharmacological profile as anti-inflammatory drug that also promotes the biosynthesis of pro-resolving LM.

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