378236-97-6Relevant academic research and scientific papers
Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3
Boyd, Scott,Brookfield, Joanna L.,Critchlow, Susan E.,Cumming, Iain A.,Curtis, Nicola J.,Debreczeni, Judit,Degorce, Sébastien L.,Donald, Craig,Evans, Nicola J.,Groombridge, Sam,Hopcroft, Philip,Jones, Neil P.,Kettle, Jason G.,Lamont, Scott,Lewis, Hilary J.,MacFaull, Philip,McLoughlin, Sheila B.,Rigoreau, Laurent J. M.,Smith, James M.,St-Gallay, Steve,Stock, Julie K.,Turnbull, Andrew P.,Wheatley, Edward R.,Winter, Jon,Wingfield, Jonathan
, p. 3611 - 3625 (2015/05/05)
A weak screening hit with suboptimal physicochemical properties was optimized against PFKFB3 kinase using critical structure-guided insights. The resulting compounds demonstrated high selectivity over related PFKFB isoforms and modulation of the target in
