378242-30-9Relevant academic research and scientific papers
Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1′ side chain
Majer, Pavel,Hin, Bunda,Stoermer, Doris,Adams, Jessica,Xu, Weizheng,Duvall, Bridget R.,Delahanty, Greg,Liu, Qun,Stathis, Marigo J.,Wozniak, Krystyna M.,Slusher, Barbara S.,Tsukamoto, Takashi
, p. 2876 - 2885 (2007/10/03)
A series of thiol-based inhibitors containing a benzyl moiety at the P1′ position have been synthesized and tested for their abilities to inhibit glutamate carboxypeptidase II (GCP II). 3-(2-Carboxy-5-mercaptopentyl)- benzoic acid 6c was found to be the m
Naaladase inhibitors for treating retinal disorders and glaucoma
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, (2008/06/13)
The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.
Thiol-based NAALADase inhibitors
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, (2008/06/13)
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effect
