37828-19-6

Basic information

• Product Name: 1-Phenylcyclobutanecarboxylic acid
• Synonyms: Phenylcyclobutane-1-carboxylic acid;1-Phenylcyclobutanecarboxylic acid
• CAS NO: 37828-19-6
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Product Categories: Acids and Derivatives;API intermediates;Carboxylic Acids;Phenyls & Phenyl-Het
• Mol File: 37828-19-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 100-102℃
• Boiling Point: 323.9 °C at 760 mmHg
• Flash Point: 149.2 °C
• Appearance: /
• Density: 1.208 g/cm³
• Vapor Pressure: 0.000104mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.39±0.20(Predicted)
• CAS DataBase Reference: 1-Phenylcyclobutanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenylcyclobutanecarboxylic acid(37828-19-6)
• EPA Substance Registry System: 1-Phenylcyclobutanecarboxylic acid(37828-19-6)

Safety Data

• Hazardous Substances Data: 37828-19-6(Hazardous Substances Data)

Usage

Description

1-Phenylcyclobutanecarboxylic acid is a chemical compound that belongs to the class of organic compounds known as benzenoids. It features a benzene ring connected to a cyclobutane ring, which is a four-membered aliphatic cycloalkane, and a carboxylic acid group. 1-Phenylcyclobutanecarboxylic acid is known for its applications in the field of organic synthesis and pharmaceuticals. It appears as a white to light yellow solid and is more soluble in organic solvents than in water.

Uses

Used in Organic Synthesis:
1-Phenylcyclobutanecarboxylic acid is used as a building block in the synthesis of various organic compounds. Its unique structure, which includes a benzene ring and a cyclobutane ring, makes it a valuable intermediate in the preparation of complex molecules.
Used in Pharmaceutical Industry:
1-Phenylcyclobutanecarboxylic acid is used as a key component in the development of pharmaceutical drugs. Its carboxylic acid group allows for the formation of esters, amides, and other functional groups, which can be utilized in the synthesis of bioactive molecules with potential therapeutic applications.
Used in Research Applications:
1-Phenylcyclobutanecarboxylic acid is used as a research chemical in academic and industrial laboratories. Its availability in fine chemical catalogs makes it accessible for researchers to study its properties, reactivity, and potential applications in various fields, such as material science and medicinal chemistry.

InChI:InChI=1/C11H12O2/c12-10(13)11(7-4-8-11)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,12,13)/p-1

Upstream product

• 1469-83-6 1-phenyl-1-cyclobutane-carbaldehyde 
• 14377-68-5 1-phenylcyclobutanecarbonitrile 
• 6940-76-7 1-iodo-3-chloro-propane 
• 28744-77-6 sodium diethyl-2-phenylmalonate 
• 935-64-8 1-phenyl-1-cyclobutanol 
• 140-29-4 phenylacetonitrile 
• 50921-39-6 1-(4-chlorophenyl)cyclobutane-1-carboxylic acid 
• 627-31-6 1,3-Diiodopropane 

Downstream Products

• 4392-30-7 phenylcyclobutane 
• 4620-67-1 1-phenylcyclobutane-carbonyl chloride 
• 7306-20-9 1,1'-Diphenyl-1,1'-bicyclobutyl 
• 1007-70-1 Methyl(1-phenylcyclobutyl)ether 
• 70775-57-4 (1-phenylcyclobutyl)methanol 
• 202737-42-6 1-(4-nitrophenyl)cyclobutanecarboxylic acid 
• 149050-19-1 1-phenylcyclobutylmethyl chloride 
• 149050-24-8 C₁₁H₁₃ClMg 
• 61492-32-8 (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(1-phenyl-cyclobutanecarbonyl)-amino]-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 
• 80606-90-2 1-Phenylcyclobutylmethylketoxim 
• 80606-00-4 1-Phenylcyclobutylmethylketoxim-pikrat 
• 17380-77-7 1-phenylcyclobutyl amine 
• 630382-89-7 4-iodophenylcyclobutylcarboxylic acid 
• 7008-48-2 1-phenyl-cyclobutanecarboxylic acid-(2-diethylamino-ethyl ester); hydrochloride 

Relevant articles and documents

Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof

The invention discloses an amide compound and derivative thereof, a preparation method, a pharmaceutical composition and application thereof. The structure of the amide compound is shown as a formula (I). The derivatives of theamide compound relate to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the above of theamide compound. The amide compound and the derivative thereof have an efficient inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing medicines for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, the prepared medicine can exert the medicine effect at the molecular level and is wide in application, and the synthesis method of the compound is simple, convenient and easy to operate.

Iridium-Catalyzed Enantioselective C(sp3)–H Borylation of Cyclobutanes

We herein report the first example of iridium-catalyzed enantioselective C(sp3)–H borylation of cyclobutanes using benzoxazoline as the directing group. The combination of a chiral bidentate boryl ligand and an iridium precursor has found to effectively catalyze C(sp3)–H borylation to afford a variety of cyclobutylboronates with good to excellent enantioselectivities. We also demonstrate the synthetic utility of the current method by converting the stereogenic C—B bond to other functionalities.

Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)

N-(5-Chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide (N-CDPCB, 1a) is found to be an inhibitor of the fat mass and obesity associated protein (FTO). The crystal structure of human FTO with 1a reveals a novel binding site for the FTO inhibitor and defines the molecular basis for recognition by FTO of the inhibitor. The identification of the new binding site offers new opportunities for further development of selective and potent inhibitors of FTO, which is expected to provide information concerning novel therapeutic targets for treatment of obesity or obesity-associated diseases.