4620-67-1

Usage

Physical state

Colorless to pale yellow liquid

Uses

Organic synthesis reactant, pharmaceutical preparation, agrochemical production, dyes and pigments production

Industry applications

Versatile building block, intermediate in pharmaceutical industry

Safety precautions

Potential irritant, handle with care, requires well-ventilated area and appropriate protective equipment.

Upstream product

• 140-29-4 phenylacetonitrile 
• 79-37-8 oxalyl dichloride 
• 37828-19-6 1-(phenyl)cyclobutane-1-carboxylic acid 
• 14377-68-5 1-phenylcyclobutanecarbonitrile 

Downstream Products

• 202736-59-2 2-(1-Pyrrolidino)ethyl 1-phenylcyclobutanecarboxylate Hydrochloride 
• 1332720-09-8 C₂₀H₁₇F₃N₄O 
• 1534433-47-0 2-(4-methoxyphenyl)-1-phenyl-N-(quinolin-8-yl)cyclobutanecarboxamide 
• 1240806-35-2 1-phenyl-N-(quinolin-8-yl)cyclobutanecarboxamide 
• 1354042-80-0 C₂₈H₂₄FN₇O₂ 
• 38117-54-3 cyclopentadienyl iron(II) dicarbonyl dimer 
• 202736-61-6 (1-Methyl-3-piperidino)methyl 1-phenylcyclobutanecarboxylate Hydrochloride 
• 202736-60-5 (1-Methyl-2-piperidino)methyl 1-phenylcyclobutanecarboxylate Hydrochloride 

Relevant academic research and scientific papers

Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof

The invention discloses an amide compound and derivative thereof, a preparation method, a pharmaceutical composition and application thereof. The structure of the amide compound is shown as a formula (I). The derivatives of theamide compound relate to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the above of theamide compound. The amide compound and the derivative thereof have an efficient inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing medicines for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, the prepared medicine can exert the medicine effect at the molecular level and is wide in application, and the synthesis method of the compound is simple, convenient and easy to operate.

In search of α-eliminations of carbon induced by sixteen electron iron: photolysis and thermolysis of derivatives of phenyl substituted cyclobutanes and cyclopropanes

Photolysis of dicarbonyl(ε5-cyclopentadienyl)(1-phenylcyclobutane-1-carbonyl)iron is proposed to give the hydride complex Ph(cyclobutenyl)Fe(Cp)(CO)H which dissociates to 1-phenylcyclobutene and FpH (Fp = ε5-cyclopentadienyldicarbonyliron).The FpH complex can oxidatively add to the sixteen electron acyl or ? complexes (Ph(cyclobutyl)-C(O)FeCp(CO) and Ph(cyclobutyl)FeCp(CO) respectively) to produce phenylcyclobutane and 1-phenylcyclobutane carboxaldehyde.Photolysis of dicarbonyl(ε5-cyclopentadienyl)(1-phenylcyclopropyl-1-carbonyl)iron gives a ? complex with no further reaction.Substitution of CO with PPh3 and thermolysis producrally substituted ?-allyl complex.In neither the cyclobutyl nor the cyclopropyl case did the reactions give isolable carbene complexes; apparently the phenyl substituent does not provide adequate stabilization of the carbene complex to allow its detection or isolation.