37832-20-5

Basic information

• Product Name: Pyridine, 3-[(aminooxy)methyl]-
• CAS NO: 37832-20-5
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Mol File: 37832-20-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-[(aminooxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-[(aminooxy)methyl]-(37832-20-5)
• EPA Substance Registry System: Pyridine, 3-[(aminooxy)methyl]-(37832-20-5)

Safety Data

• Hazardous Substances Data: 37832-20-5(Hazardous Substances Data)

Usage

Description

Pyridine, 3-[(aminooxy)methyl]-, also known as oxime, is a chemical compound with the molecular formula C7H8N2O. It features a pyridine ring with an aminooxy methyl group attached to it, making it a versatile reagent in organic synthesis.

Uses

Used in Pharmaceutical and Agrochemical Industries:
Pyridine, 3-[(aminooxy)methyl]is used as a reagent for converting carbonyl compounds into oximes, which are valuable intermediates in the production of pharmaceuticals and agrochemicals. These oximes contribute to the synthesis of various organic compounds.
Used as a Chelating Agent:
Oxime serves as a chelating agent for metal ions, which is crucial in various chemical processes and applications.
Used in Paints, Dyes, and Adhesives Industry:
Pyridine, 3-[(aminooxy)methyl]is used as a stabilizer for maintaining the color and texture of paints, dyes, and adhesives, ensuring their quality and performance over time.
Used in Material Development and Chemical Research:
Oxime has potential applications in the development of new materials and is utilized in chemical research to explore its properties and possible uses further.
Safety Note:
It is important to handle Pyridine, 3-[(aminooxy)methyl]with caution, as it can be toxic and irritating to the skin, eyes, and respiratory system if not used properly.

Upstream product

• 100-55-0 3-hydroxymethylpyridin 
• 30777-95-8 N-pyridin-3-ylmethoxy-phthalimide 

Downstream Products

• 792913-89-4 tert-butyl 1-methyl-4-[(3-pyridinylmethoxy)imino]cyclohexylcarbamate 

Relevant articles and documents

IDO inhibitors

Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

INHIBITORS OF FLAVIVIRIDAE VIRUSES

Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Synthesis and fungicidal activity of macrolactams and macrolactones with an oxime ether side chain

Three series of novel macrolactams and macrolactones - 12-alkoxyimino- tetradecanlactam, 12-alkoxyiminopentadecanlactam, and 12-alkoxyiminodecanlactone derivatives (7A, 7B, and 7C) - were synthesized from corresponding 12-oxomacrolactams and 12-oxomacrolactone. Their structures were confirmed by 1H NMR and elemental analysis. The Z and E isomers of 7A and 7B were separated, and their configurations were determined by 1H NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kuehn. It is interesting that the Z and E isomers of most of the compounds have quite different fungicidal activities. The fact that the compounds have a gradual increase of fungicidal activity in the order of 7A, 7C, and 7B indicated that the macrocyclic derivatives with a hydrogen-bonding acceptor (=N-O-) and a hydrogen-bonding donor (-CONH-) on the ring, and a three methylenes distance (CH2CH2CH2) between these two functional groups, exhibited the best fungicidal activity. The bioassay also showed that 7B not only has good fungicidal activity but also may have a broad spectrum of fungicidal activities.