37833-24-2Relevant academic research and scientific papers
Synthesis and characterization of tributyltin derivatives from 4-oxo-4-(arylamino)butanoic acids and their in vitro biological activity against cervical cancer cell lines
Rojas-Oviedo, Irma,Camacho-Camacho, Carlos,Snchez-Snchez, Luis,Crdenas, Jorge,Lpez-Muoz, Hugo,Eugenio-Robledo, Hugo,Velzquez, Israel,Alfredo Toscano, Rubn
, p. 884 - 891 (2015/02/19)
Uterine (cervix and corpus) cancer is one of the major causes ofmortality in women inMexico. Organotin carboxylated derivatives have shown high cytotoxic activity against various cell lines of human origin. We describe the synthesis of three new tri-n-but
Synthesis and characterization of tributyltin derivatives from 4-oxo-4-(arylamino)butanoic acids and their in vitro biological activity against cervical cancer cell lines
Rojas-Oviedo, Irma,Camacho-Camacho, Carlos,Sánchez-Sánchez, Luis,Cárdenas, Jorge,L?pez-Mu?oz, Hugo,Eugenio-Robledo, Hugo,Velázquez, Israel,Toscano, Rubén Alfredo
, p. 884 - 891 (2015/08/25)
Uterine (cervix and corpus) cancer is one of the major causes of mortality in women in Mexico. Organotin carboxylated derivatives have shown high cytotoxic activity against various cell lines of human origin. We describe the synthesis of three new tri-n-b
Novel pyrazole derivatives as anticancer and radiosensitizing agents
Aly,El-Gazzar
experimental part, p. 105 - 112 (2012/09/07)
The present article describes the synthesis of some novel pyrrole, pyrazolo[4,3-d]oxazole, pyrrolo[2,3-b]pyridine, 1,2,3-triazole and oxoazetidin derivatives incorporating pyrazole moiety, the structures of which were confirmed by elemental analyses and s
Studies on new cyclic imides obtained from aminophenazone with analgesic properties / Potent effects of a 3,4-dichloromaleimide derivative
De Campos, Fatima,Correa, Rogerio,De Souza, Marcia Maria,Yunes, Rosendo Augusto,Nunes, Ricardo Jose,Cechinel-Filho, Valdir
, p. 455 - 461 (2007/10/03)
This paper describes the synthesis of new cyclic imides obtained by reaction with aminophenazone (CAS 58-15-1, 4-aminoantipyrine) and different anhydrides with further cyclization with acetic acid under reflux. Their Structures were confirmed by spectral data (IR and NMR) and elemental analysis. The analgesic activity of the synthesized compounds was investigated initially with the writhing test in mice and the most promising compound, a 3,4-dichloromaleimide derivative (3), was analyzed using other models of nociception. The results indicated that compound 3 exerts potent analgesic activity in mice, being more active than some reference drugs. The analgesia caused by this compound was not reversed by naloxone in the writhing test. In the hotplate test, compound 3 did not increase the latency period of pain induced by thermal stimuli, confirming that it does not interact with opioid systems.
