37859-26-0Relevant articles and documents
An efficient synthesis of benzothiazoles by direct condensation of carboxylic acids with 2-aminothiophenol under microwave irradiation
Chakraborti, Asit K.,Selvam,Kaur, Gurmeet,Bhagat, Srikant
, p. 851 - 855 (2004)
Carboxylic acids are converted to benzothiazoles by direct condensation with 2-aminothiophenol under microwave irradiation in the absence of solvent.
Synthesis and structure-activity relationships of new antimicrobial active multisubstituted benzazole derivatives
Yildiz-Oren, Ilkay,Yalcin, Ismail,Aki-Sener, Esin,Ucarturk, Nejat
, p. 291 - 298 (2007/10/03)
A series of multisubstituted benzoxazoles, benzimidazoles, and benzothiazoles (5-7) as non-nucleoside fused isosteric heterocyclic compounds was synthesized and tested for their antibacterial activities against various Gram-positive and Gram-negative bacteria and antifungal activity against the fungus Candida albicans. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 100 and 3.12 μg/ml. Structure-activity relationships (SAR) studies revealed that benzothiazole ring system enhanced the antimicrobial activity against Staphylococcus aureus. In these sets of non-nucleoside fused heterocyclic compounds electron withdrawing groups at position 5 of the benzazoles increased the activity against C. albicans.
