37867-75-7

Upstream product

• 452070-80-3 6-(4-aminophenyl)phenanthridine 
• 74-88-4 methyl iodide 
• 13190-50-6 4-dimethylaminophenyllithium 
• 400820-15-7 2'-fluoro-[1,1'-biphenyl]-2-carbonitrile 
• 95-14-7 1,2,3-Benzotriazole 
• 1083169-40-7 phenyl-N-biphenyl-2-yl-4-(dimethylamino)benzimidoselenoate 
• 1197-19-9 4-cyano-N,N-dimethylaniline 
• 2113-51-1 2-iodobiphenyl 
• 98-80-6 phenylboronic acid 
• 615-36-1 2-bromoaniline 
• 109-72-8 n-butyllithium 
• 182057-40-5 [4-(Benzotriazol-1-yl-phenyl-methyl)-phenyl]-dimethyl-amine 
• 851466-57-4 N-biphenyl-2-yl-4-dimethylaminobenzamide 
• 4755-50-4 4-(dimethylamino)benzoyl chloride 

Relevant academic research and scientific papers

Metal-free nitrogenation of 2-acetylbiphenyls: Expeditious synthesis of phenanthridines

An intermolecular nitrogenation reaction toward the synthesis of phenanthridines has been developed. This metal-free protocol provides a novel nitrogen-incorporation transformation using azides as the nitrogen source. Phenanthridines, which are of great interest in pharmaceutical and medicinal chemistry, are synthesized efficiently in one step. Moreover, the byproducts derived from the Schmidt reaction are inhibited, which further demonstrated the high chemoselectivity of this transformation.

Synthesis of phenanthridine derivatives via cascade annulation of diaryliodonium salts and nitriles

A cascade coupling reaction toward a variety of phenanthridine derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction of diaryliodonium salts and nitriles, and undergoes cyclization into the phenanthridine core.

Palladium and radical routes to phenanthridines

Two routes to phenanthridines are reported; a palladium-mediated route using imidoyl-selanides as precursors and a modified radical route using aryl imines as starting materials. ARKAT-USA, Inc.

Palladium-mediated synthesis of phenanthridines: The first report of palladium insertion into imidoyl selenides

Imidoyl phenyl selenides have been shown to be precursors to phenanthridines, when treated with Pd(PPh3)4 under reflux in toluene in the presence of a base, giving reasonable yields. It is proposed that insertion of palladium into th

Convergent synthesis of 6-substituted phenanthridines via anionic ring closure

Chemical equation presented The addition of organometallic derivatives to the cyano group of 2-(2-fluorophenyl)benzonitrile followed by intramolecular nucleophilic substitution produces 6-substituted phenanthridines. Alkyllithiums, aryllithiums, and steri

Novel Heteroatom-Linked Analogues of Trityl Radicals: Diaryl(benzotriazol-1-yl)methyl Radical Dimers

The lithiation of diaryl(benzotriazol-1-yl)methanes followed by addition of iodine generates phenanthridines and dimers of hitherto unknown trityl analogues in which the radical center is directly attached to a heteroatom. These dimers differ from those of triarylmethyl radicals by not dissociating in solution, but variable temperature ESR measurements provided direct evidence for the formation of the corresponding diaryl(benzotriazol-1-yl)methyl radicals as intermediates in solution.

Radical Mediated Synthesis of 6-Arylphenanthridines via Benzotriazole Ring-opening

Lithiation of diarylbenzotriazol-1-ylmethanes followed by addition of copper(I) iodide gave 6-arylphennathridine derivatives in moderate yields.When the two aryl groups were the same or contained very different electron densities, only one product was obt