37875-81-3Relevant academic research and scientific papers
An eficient one-pot synthesis of 1,4-dihydropyridines catalyzed by magnetic nanocrystalline Fe3O4
Yang, Shu-Hong,Zhao, Fei-Yang,Lue, Hong-Yan,Deng, Jia,Zhang, Zhan-Hui
, p. 1126 - 1129 (2013/01/15)
An efficient approach for one-pot three-component reaction of aromatic amines, α,β-unsaturated aldehydes and β-keto esters using magnetic nanocrystalline Fe3O4 as a catalyst has been described. The corresponding 1,4-dihydropyridines
Synthesis and biological evaluation of N-aryl-1,4-dihydropyridines as novel antidyslipidemic and antioxidant agents
Kumar, Atul,Maurya, Ram Awatar,Sharma, Siddharth,Kumar, Mukesh,Bhatia, Gitika
experimental part, p. 501 - 509 (2010/04/02)
N-aryl-1,4-dihydropyridines 2a-n were synthesized via iodine catalyzed three-component reaction of cinnamaldehydes, anilines and 2-keto esters in methanol. The synthesized compounds were screened for their antidyslipidemic and antioxidant activity in vivo
Organocatalysed three-component domino synthesis of 1,4-dihydropyridines under solvent free conditions
Kumar, Atul,Maurya, Ram Awatar
, p. 3477 - 3482 (2008/09/20)
An organocatalysed protocol for one-pot synthesis of 1,4-dihydropyridines via three-component coupling of cinnamaldehyde, aniline and β-keto esters under solvent free conditions at ambient temperature is reported. The reaction is generally very fast and the products are obtained in high yield. The catalytic activity of small organic molecules like amino acids (acidic, basic and neutral), ephedrine and cinchona alkaloids was studied.
Sulfonic acid functionalized silica: An efficient heterogeneous catalyst for a three-component synthesis of 1,4-dihydropyridines under solvent-free conditions
Das, Biswanath,Suneel, Kanaparthy,Venkateswarlu, Katta,Ravikanth, Bommena
, p. 366 - 368 (2008/12/23)
Sulfonic acid functionalized silica catalyzed the three-component reaction of aromatic amines, α,β -unsaturated aldehydes and β-keto esters forming the corresponding 1,4-dihydropyridines in short reaction times and in high yields.
A new three-component domino synthesis of 1,4-dihydropyridines
Sridharan, Vellaisamy,Perumal, Paramasivan T.,Avenda?o, Carmen,Menéndez, J. Carlos
, p. 4407 - 4413 (2007/10/03)
Cerium ammonium nitrate (CAN) catalyzed the three-component domino reaction between aromatic amines, α,β-unsaturated aldehydes, and ethyl acetoacetate, providing an efficient new entry into 1,4-dihydropyridines. This new reaction requires very mild reaction conditions, has water as the only side product and is complementary to the classical Hantzsch synthesis in that it is well suited to the preparation of N-aryl-5,6-unsubstituted dihydropyridines. Experiments in the presence of a radical trap suggest that a one-electron oxidative mechanism can be excluded and that CAN acts as a Lewis acid.
Facile, regioselective [4 + 2] cycloaddition involving 1-aryl-4-phenyl-1-azadienes and allenic esters: An efficient route to novel substituted 1-aryl-4-phenyl-1,4-dihydropyridines
Ishar,Kumar, Kamal,Kaur, Sumanjit,Kumar, Shiv,Girdhar, Navdeep K.,Sachar, Satish,Marwaha, Alka,Kapoor, Ashish
, p. 2133 - 2136 (2007/10/03)
(Matrix presented) 1-Aryl-4-phenyl-1-azadienes undergo facile, regioselective [4 + 2] cycloaddition to the C2,C3 π-bond of allenic esters in refluxing benzene, and the formed adducts undergo a 1,3-H shift to afford novel 2-alkyl-1-aryl-3-ethoxycarbonyl-4-
