378756-01-5Relevant academic research and scientific papers
Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer
Shigenaga, Akira,Hirakawa, Hiroko,Yamamoto, Jun,Ogura, Keiji,Denda, Masaya,Yamaguchi, Keiko,Tsuji, Daisuke,Itoh, Kohji,Otaka, Akira
, p. 3984 - 3990 (2011)
Sphingolipids, recognized as membrane constructs and as key signaling molecules, have been studied to examine intracellular function. Some caged sphingolipids that release parent sphingolipids after exposure to UV-irradiation have been previously developed, but caged ceramide has yet to be reported. In this study, we report the design and synthesis of a caged ceramide. Photo-irradiation experiment clarified that the caged ceramide can be successfully converted to the parent ceramide by UV-irradiation. Introduction of an alkyne-handle moiety for further modification of the caged ceramide is also reported.
