378791-99-2Relevant academic research and scientific papers
Synthesis and biological activity of 4′-thio-L-xylofuranosyl purine nucleosides
Tiwari, Kamal N.,Messini, Lea,Montgomery, John A.,Secrist III, John A.
, p. 1895 - 1906 (2007/10/03)
□ A series of some new 4′-thio-L-xylofuranosyl nucleosides were prepared and evaluated as potential anticancer agents. A versatile sugar intermediate for direct coupling with the purine moiety is also synthesized by an efficient and high-yielding route. Proof of structure and configuration at all chiral centers of the nucleosides was obtained by proton NMR. All target compounds were evaluated in a series of human cancer cell lines in vitro. The details of the synthesis of the carbohydrate precursor 1-O-acetyl-2,3,5-tri-O- benzyl-4-thio-L-xylofuranose (6) and corresponding purine nucleosides are presented in the manuscript. Copyright Taylor & Francis Group, LLC.
Synthesis and biological activity of 4′-thio-L-xylofuranosyl nucleosides
Tiwari,Messini,Montgomery,Secrist III
, p. 743 - 746 (2007/10/03)
A series of 4′-thio-L-xylofuranosyl nucleosides were prepared and evaluated as potential anticancer and antiviral agents. The details of a convenient and high-yielding synthesis of the carbohydrate precursor 1-O-acetyl-2,3,5-tri-O-benzyl-4- thio-L-xylofuranose (6) are presented. Proof of structure and configuration at all chiral centers of the nucleosides was obtained by proton and carbon NMR. All target compounds were evaluated in a series of human cancer cell lines in culture and as antiviral agents.
