37893-28-0Relevant academic research and scientific papers
1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT
-
Page/Page column 164, (2015/02/25)
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
Synthesis, characterization and electronic properties of some hetero-arylene vinylene oligomers
Van Der Looy, Johan F.A.,Thys, Gerd J.H.,Dieltiens, Pieter E.M.,De Schrijver, Daniel,Van Alsenoy, Christian,Geise, Herman J.
, p. 15069 - 15084 (2007/10/03)
The synthesis and characterization is reported of six 2,5-distyryl-heteroarylenes (BXB compounds) and 1,4-bis{2-(heteroaryl-2-yl) ethenyl}benzenes (XBX compounds) containing the thienyl, furanyl or N-methylpyrryl as the heteroarylene moiety. By means of NMR and UV/Vis spectroscopy the electronic structure was probed. Quantum mechanical calculations using the semiempirical CNDO/S-CI approach rationalize the experimental findings and support the peak assignments.
A Convenient General Method for the Synthesis of Pyrrole-2,5-dicarbaldehydes
Cadamuro, Silvano,Degani, Iacopo,Fochi, Rita,Gatti, Antonella,Piscopo, Laura
, p. 2939 - 2944 (2007/10/02)
A new general method for the synthesis of pyrrole-2,5-dicarbaldehyde and its 3-mono- and 3,4-disubstituted derivatives is reported.It involves the intermediate formation of the corresponding 2,5-bis(1,3-benzodithiol-2-yl)pyrroles followed by hydrolysis with HgO-35percent aq.HBF4-DMSO.Pyrrole-2,5-dicarbaldehyde was obtained in overall yields of 43-65percent, whilst that of the derivatives was 32-90percent.Moreover the methylation of the corresponding dithiolic intermediate with further hydrolysis resulted in the formation of 1-methylpyrrole-2,5-dicarbaldehyde in 90percent overall yield.
Synthesis and properties of 2,3,17,18-tetramethyl-1,19--bilindione and 2,3,17,18,22,23-hexamethyl-23-hydro-1,19--bilindion-10-enium trifluoroacetate, two biliverdin model compounds
Groot, J. A. de,Steen, R. van der,Lugtenburg, J.
, p. 347 - 352 (2007/10/02)
The biliverdin model compound 1 could be prepared in high yield by acid-catalyzed condensation of 3,4-dimethyl-2,2'-pyrromethen-5-one (9) with the novel 3,4-dimethyl-5'-formyl-2,2'-pyrromethen-5-one (11).The biliverdinium model compound 3 could analogously be prepared quantitatively from 1',3,4-trimethyl-2,2'-pyrromethen-5-one (10) and 5'-formyl-1',3,4-trimethyl-2,2'-pyrromethen-5-one (12).The analytical, chemical, photochemical and photophysical properties of these model compounds have been investigated.The data so obtained are compared with known aspects of the natural biliverdin compounds.
PYRROLE CHEMISTRY. XXIV. THE VILSMEIER FORMYLATION AND CYANATION OF PYRROLE ACETALS. A SYNTHESIS OF PYRROLE-2,3,5-TRICARBOXALDEHYDE
Loader, Charles E.,Barnett, Graham H.,Anderson, Hugh J.
, p. 383 - 389 (2007/10/02)
The preparation of the acetals of a number of pyrrole mono- and dicarboxaldehydes is described.It is shown that, provided the reactivity of the unsubstituted ring positions on the pyrrole nucleus is not too low, a carboxaldehyde or a carbonitrile group may be substituted on the pyrrole ring using the Vilsmeier reaction or chlorosulfonyl isocyanate respectively. Vilsmeier formylation of the diacetal, 2,4-di(5,5-dimethyl-1,3-dioxan-2-yl)-pyrrole, followed by hydrolysis gave pyrrole-2,3,5-tricarboxaldehyde.
