39604-60-9

Usage

Uses

Used in Organic Synthesis:
PYRROLE-2,5-DICARBOXALDEHYDE is used as a building block for the synthesis of complex organic compounds due to its reactive carboxaldehyde groups, which can participate in a variety of chemical reactions, facilitating the formation of diverse molecular structures.
Used in Pharmaceutical Development:
PYRROLE-2,5-DICARBOXALDEHYDE is used as a starting material in the development of pharmaceuticals, leveraging its unique chemical properties to create new drug candidates with potential therapeutic applications.
Used in Materials Science:
PYRROLE-2,5-DICARBOXALDEHYDE is utilized in the field of materials science for the design and synthesis of novel materials, potentially contributing to advancements in areas such as polymers, sensors, and other high-tech applications.

Upstream product

• 39604-59-6 2,5-bis-(1,3-diacetyl-1,2-dihydrobenzimidazol-2-yl)pyrrole 
• 70582-64-8 ethyl 2-cyano-3-(5-formyl-1H-pyrrol-2-yl)-acrylate 
• 121643-36-5 2-Bromo-6-diisopropylamino-1-azafulvene 
• 68-12-2 N,N-dimethyl-formamide 
• 150312-34-8 (E)-ethyl 2-cyano-3-(5-formyl-1H-pyrrol-2-yl)acrylate 
• 123293-46-9 (E)-2-cyano-3-(pyrrol-2-yl)-2-propenoic acid ethyl ester 
• 1003-29-8 2-pyrrole aldehyde 
• 1166995-02-3 N-tosyl-2,5-diformylpyrrole 
• 6249-04-3 (1H-pyrrole-2,5-diyl)dimethanol 
• 101605-99-6 1H,1'H-2,2'-pyrrole-2,5-diyl-bis-benzoimidazole 
• 153850-72-7 2,5-bis(1,3-benzodithiol-2-yl)-1-phenylsulfonylpyrrole 
• 155664-02-1 1-phenylsulfonylpyrrole-2,5-dicarbaldehyde 
• 64435-30-9 N⁵,N⁵,N¹⁰,N¹⁰-tetramethyl-5,10-dihydrodipyrrolo[1,2-a:1',2'-d]pyrazine-5,10-diamine 
• 58488-39-4 2,5-bis(1,3-benzodithiol-2-yl)pyrrole 

Downstream Products

• 95713-65-8 5-(4-Diethoxyphosphoryl-1,3-butadienyl)-2-pyrrolcarbaldehyd 
• 95713-66-9 5-[(1E,3E)-4-(Diethoxy-phosphoryl)-buta-1,3-dienyl]-1H-pyrrole-2-carboxylic acid 
• 603-35-0 triphenylphosphine 
• 791-28-6 Triphenylphosphine oxide 
• 37893-28-0 1-methyl-1H-pyrrole-2,5-diformaldehyde 
• 503536-57-0 Co₄O(O₂CC(CH₃)3)4(C₆H₅N₂C₇H₄C₄H₂NC₇H₄N₂C₆H₅)2*C₆H₅CH₃ 
• 205754-13-8 C₆H₅C₆H₄OCH₃BC₄H₂N(CHNC₃H₇)CHO 
• 205754-12-7 C₆H₅C₆H₄OCH₃BC₄H₂N(CHNC₃H₇)2 
• 160680-85-3 1-benzyl-1H-pyrrole-2,5-bis(carbaldehyde) 
• 1337989-77-1 1-((4S,5R)-4,6-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-2-hydroxyhexyl)-5-((tetrahydro-2H-pyran-2-yloxy)methyl)-1H-pyrrole-2-carbaldehyde 
• 1337989-78-2 5-((tetrahydro-2H-pyran-2-yloxy)methyl)-1-((3S,4S,5R)-3,4,6-tris(benzyloxy)-5-(tert-butyldimethylsilyloxy)-2-hydroxyhexyl)-1H-pyrrole-2-carbaldehyde 
• 1337989-94-2 5-((tert-butyldimethylsilyloxy)methyl)-1-((3S,4S,5R)-3,4,6-tris(benzyloxy)-5-(tert-butyldimethylsilyloxy)-2-hydroxyhexyl)-1H-pyrrole-2-carbaldehyde 

Relevant academic research and scientific papers

Stereoselective synthesis of acortatarins A and B

Acortatarins A and B have been synthesized via stereoselective spirocyclizations of glycals. Mercury-mediated spirocyclization of a pyrrole monoalcohol side chain leads to acortatarin A. Glycal epoxidation and reductive spirocyclization of a pyrrole dialdehyde side chain leads to acortatarin B. Acid equilibration and crystallographic analysis indicate that acortatarin B is a contrathermodynamic spiroketal with distinct ring conformations compared to acortatarin A.

Synthesis and Structure of 2,5-Bis[N-(2,6-mesityl)iminomethyl]pyrrolylcobalt(II): Evidence for One-Electron-Oxidized, Redox Noninnocent Ligand Behavior

The title complex Co(Mes2pyr)Cl2 is prepared from CoCl2 and (Mes2pyr)H. Instead of the expected (Mes2pyr)CoCl complex, a complex with formula (Mes2pyr)CoCl2 is isolated wherein the angle strain of the Mes2pyr ligand results in metal ligation by only two of the three ligand donor atoms. Careful examination of structural, spectroscopic, and magnetic features indicates this compound is best described as a complex of high-spin Co(II) with a neutral radical ligand.

Absorption and fluorescence properties of chalcones having pyrrole or indole moiety

2′-Hydroxychalcone derivatives having pyrrole ring have been synthesized and their absorption and fluorescence properties have been examined in connection to intramolecular hydrogen bonding.

Double intramolecular hydrogen transfer assisted dual emission in a carbazole-embedded porphyrin-like macrocycle

The introduction of a pyrrole ring at one of themesopositions of carbazole-based porphyrins lowers the structural symmetry and results in dual emission, which strongly depends on the excitation wavelength and temperature. The origin of dual emission induced by NH-tautomerism is confirmedviaphotophysical and DFT calculations.

Carbohydrate receptors combining both a macrocyclic building block and flexible side arms as recognition units: Design, syntheses, and binding studies

Carbohydrate receptors combining a macrocyclic building block and two flexible side arms were designed on the base of the analysis of the binding motifs found in the crystal structures of the complexes formed between artificial receptors and monosaccharides, reported previously by our group. Binding studies in two-phase systems, such as extractions of sugars from water into organic phase, as well as in homogeneous organic media, using 1H NMR and fluorescence spectroscopic titrations, confirmed the suitability of the designed compounds to act as highly effective and selective carbohydrate receptors. Depending on the nature of the bridges and side arms used as the building blocks, various receptors with different binding properties could be developed. The obtained results confirmed the validity of the receptor design and revealed that crystalline receptor-sugar complexes are particularly a valuable basis for the design of new effective receptor systems.

Total synthesis and stereochemical revision of acortatarins A and B

A first total synthesis of acortatarins A, B, and an enantiomer of the proposed structure of acortatarin B is described by using readily available d-sugars. This convergent total synthesis revealed the revision of the absolute configuration of acortatarin A and structural revision of acortatarin B. The key steps involved are regioselective epoxide opening with deprotonated 2,5-disubstituted pyrrole and spiroketalization.

Oxidation of 2,5-dialkylpyrrole derivatives with cerium(IV) ammonium nitrate

A new four-step procedure for the synthesis of 2,5-diformylpyrrole from hexane-2,5-dione was developed. The oxidation reaction of substituted 2,5-dialkylpyrroles with cerium(IV) ammonium nitrate (CAN) has been studied in detail. It was found that the outc

Pincer ligands based on α-amino acids: I. Synthesis of polydentate ligands from pyrrole-2,5-dicarbaldehyde

New chiral pincer ligands having CH=N moieties were synthesized by condensation of 1H-pyrrole-2,5-dicarbaldehyde with l-methionine and l-histidine methyl esters. Their reduction under mild conditions (NaBH4, -30°C) gave the corresponding amine ligands in high yields. An improved procedure for the preparation of 1H-pyrrole-2,5-dicarbaldehyde was proposed.

Novel aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity

The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.

Novel compounds possessing antibacterial, antifungal or antitumor activity

The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.