37901-73-8

Upstream product

• 85302-07-4 2-(dimethylaminomethylene)cyclohexane-1,3-dione 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 1203661-58-8 C₁₃H₁₄FN₃ 
• 1611491-36-1 N-[1-(4-fluorophenyl)indazol-4-yl]acetamide 
• 1611491-28-1 1-(4-fluorophenyl)-6,7-dihydro-5H-indazol-4-one oxime 
• 1610785-86-8 (R)-1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-ol 
• 1610785-84-6 (S)-1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-ol 
• 1383735-60-1 1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene 
• 1383735-07-6 C₁₃H₁₅BrFN₃ 
• 1383735-06-5 C₁₇H₂₃BrFN₃OS 
• 1383735-05-4 C₁₇H₂₁BrFN₃OS 
• 1383735-04-3 C₁₃H₁₂BrFN₂O 
• 37901-75-0 1-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-1H-indazol-4-ol 
• 1383735-61-2 (S)-1-(4-fluorophenyl)-5-methyl-1,4,5,6,7,8-hexahydro-1,2,4-triazaazulene 
• 1383735-13-4 C₁₄H₁₇BrFN₃ 
• 1383735-12-3 C₁₈H₂₅BrFN₃OS 

Relevant academic research and scientific papers

A novel synthetic approach to 4-acetamido-1-arylindazoles via Semmler-Wolff rearrangement of 1-aryl-6,7-dihydro-5H-indazol-4-one oxime

A simple and efficient procedure for the syntheses of 4-acetamido-1- arylindazoles from corresponding 1-aryl-6,7-dihydro-5H-indazol-4-one oximes by Semmler-Wolff aromatization using acetic anhydride and sodium iodide is reported.

Identification, synthesis, and pharmacological evaluation of tetrahydroindazole based ligands as novel antituberculosis agents

The resurgence of tuberculosis (TB), the incidence of drug-resistant strains of Mycobacterium tuberculosis (MTB), and the coinfection between TB and HIV have led to serious infections, high mortality, and a global health threat, resulting in the urgent search for new classes of antimycobacterial agents. Herein, we report the identification of a novel class of tetrahydroindazole based compounds as potent and unique inhibitors of MTB. Compounds 6a, 6m, and 6q exhibited activity in the low micromolar range against replicating Mycobacterium tuberculosis (R-TB) phenotype, with minimum inhibitory concentrations (MICs) of 1.7, 1.9, and 1.9 μM, respectively, while showing no toxicity to Vero Ccells. Moreover, studies aimed to assess the in vitro metabolic stability of 6a and 6m in mouse liver microsomes and in vivo pharmacokinetic profiles in plasma levels gave satisfactory results. This research suggests that tetrahydroindazole based anti-TB compounds can serve as a promising lead scaffold in developing new drugs to combat tuberculosis infections.