85302-07-4Relevant articles and documents
NEW THERAPEUTIC AGENTS FOR THE TREATMENT OF HAEMATOLOGICAL PATHOLOGIES
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Page/Page column 26-27, (2021/03/05)
The present invention relates to compounds having a tetracyclic system and the use thereof as new therapeutic agents in the treatment of acute myeloid leukemia (AML), preferably in FLT3/ITD hemizygote patients resistant to conventional therapies. The invention also relates to 5,7-dihydro-4H-[1,3]thiazolo[4,5-e]isoindol-2-amine compounds useful as intermediates for the synthesis of tetracyclic imidazo[2',1':2,3][1,3]thiazolo[4,5-e]isoindole compounds.
Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold
Salerno, Silvia,Amendola, Giorgio,Angeli, Andrea,Baglini, Emma,Barresi, Elisabetta,Marini, Anna Maria,Ravichandran, Rahul,Viviano, Monica,Castellano, Sabrina,Novellino, Ettore,Da Settimo, Federico,Supuran, Claudiu T.,Cosconati, Sandro,Taliani, Sabrina
, (2021/06/07)
Carbonic Anhydrases (CAs) are pharmaceutically relevant targets for the treatment of several disease conditions. The ubiquitous localization of these enzymes and the high homology shared by the different isoforms represent substantial impediments for the
GPR52 MODULATOR COMPOUNDS
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Page/Page column 45; 48; 58-59, (2021/05/15)
The disclosures herein relate to novel compounds of Formula (1): (1) and salts thereof, wherein R1, Q, X, Y and Z are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with GPR52 receptors.