37905-07-0

Basic information

• Product Name: jolkinolide A
• Synonyms: jolkinolide A;(4aR,6aS,7aβ)-2,3,4,4aα,5,6,11aα,11b-Octahydro-4,4,8,11bβ-tetramethyl-1H-oxireno[1,10a]phenanthro[3,2-b]furan-9(7aH)-one;(5β,9β,10α)-8β,14β:12,16-Diepoxyabieta-11,13(15)-dien-16-one
• CAS NO: 37905-07-0
• Molecular Formula: C20H26O3
• Molecular Weight: 314.41864
• Mol File: 37905-07-0.mol

Chemical Properties

• Boiling Point: 479.5°Cat760mmHg
• Flash Point: 206.7°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 2.35E-09mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: jolkinolide A(CAS DataBase Reference)
• NIST Chemistry Reference: jolkinolide A(37905-07-0)
• EPA Substance Registry System: jolkinolide A(37905-07-0)

Safety Data

• Hazardous Substances Data: 37905-07-0(Hazardous Substances Data)

Usage

Uses

Used in Regenerative Medicine:
Jolkinolide A is used as a bone marrow mesenchymal stem cell osteogenic differentiation accelerator for promoting the differentiation of these stem cells into bone-forming cells. This application can be particularly useful in the treatment of bone-related disorders, such as osteoporosis, fractures, and other conditions that require enhanced bone regeneration.
Used in Drug Delivery Systems:
In the pharmaceutical industry, jolkinolide A can be employed as a component in drug delivery systems, specifically for targeting bone-related conditions. Its ability to enhance the osteogenic differentiation of stem cells can be utilized to improve the efficacy of drug delivery systems, such as nanoparticles or hydrogels, that are designed to release therapeutic agents at the site of bone injury or disease.
Used in Tissue Engineering:
Jolkinolide A can also be used in tissue engineering applications, where it can be incorporated into scaffolds or other biomaterials to promote the growth and differentiation of bone marrow mesenchymal stem cells into functional bone tissue. This can be particularly useful in the development of artificial bone grafts or other tissue-engineered constructs for the repair and replacement of damaged or diseased bone tissue.

InChI:InChI=1/C20H26O3/c1-11-15-12(22-17(11)21)10-14-19(4)8-5-7-18(2,3)13(19)6-9-20(14)16(15)23-20/h10,13-14,16H,5-9H2,1-4H3/t13-,14+,16-,19-,20+/m1/s1

Downstream Products

• 37905-08-1 jolkinolide B 
• 86746-86-3 jolkinolide B 

Relevant articles and documents

Total Synthesis of (+/-)-Jolkinolide A and B

The first efficient synthesis of jolkinolide A and B from the diosphenol (7) is reported; the new synthetic method described may find use in the preparations of 4-ylidene-2,3-substituted butenolides.

Natural crag root of beijing euphorbia lactone Jolkinolide A and B synthetic method

The invention provides a method for synthesizing a jolkinolide A component and a jolkinolide B component which serve as main active components of a traditional Chinese medicine euphorbia fischeriana. The natural jolkinolide A and B is obtained by simple and high-efficiency synthesis through a series of chemical reactions by taking low-cost and readily-available p-13,19-dyhydroxyl kaurene; a preparation condition, a preparation process and important spectral structures and physical property data of all midbodies and target compounds are supplied.

Efficient Synthesis of Jolkinolides A and B from Steviol

Jolkinolides, isolated from Euphorbia fischeriana Steud, are naturally occurring tetracyclic ent-abietane diterpenes, some of which exhibit promising antitumor and other biological activity. An efficient strategy for the synthesis of jolkinolides A and B is described starting from readily available steviol in 10 and 11 steps with total yields of over 10%, respectively.

TOTAL SYNTHESIS OF (+/-)-JOLKINOLIDE A, B, AND E UTILIZING A NEW MILD ESTERIFICATION FOLLOWED BY INTRAMOLECULAR WITTIG-HORNER REACTION

Jolkinolide A, B, and E were efficiently synthesized from 9-methoxycarbonyl-4,4,10-trimethyl-Δ6-8-octalone 8 through Δ8(14)-podocalpen-13-one 12.A new synthetic method of γ-ylidenbutenolide consisting of mild esterification and the s