37905-08-1

Basic information

• Product Name: jolkinolide B
• Synonyms: jolkinolide B;(4aR,6aS,7aβ,10aR)-1,2,3,4,4aα,5,6,11aβ,11bα,11c-Decahydro-4,4,8,11cβ-tetramethylbisoxireno[1,10a:3,4]phenanthro[3,2-b]furan-9(7aH)-one
• CAS NO: 37905-08-1
• Molecular Formula: C20H26O4
• Molecular Weight: 330.41804
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 37905-08-1.mol

Chemical Properties

• Melting Point: 213-215℃
• Boiling Point: 497.1oC at 760 mmHg
• Flash Point: 219.8oC
• Appearance: /
• Density: 1.28±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 5.08E-10mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: jolkinolide B(CAS DataBase Reference)
• NIST Chemistry Reference: jolkinolide B(37905-08-1)
• EPA Substance Registry System: jolkinolide B(37905-08-1)

Safety Data

• Hazardous Substances Data: 37905-08-1(Hazardous Substances Data)

Usage

Definition

ChEBI: A natural product found in Euphorbia fischeriana.

InChI:InChI=1/C20H26O4/c1-10-12-14-19(22-14)9-6-11-17(2,3)7-5-8-18(11,4)13(19)15-20(12,23-15)24-16(10)21/h11,13-15H,5-9H2,1-4H3/t11-,13+,14-,15-,18-,19+,20-/m1/s1

Upstream product

• 37905-07-0 jolkinolide A 
• 37905-07-0 jolkinolide A 

Relevant articles and documents

A 17 - hydroxy - crag root of beijing euphorbia lactone B synthetic method of

The invention provides a semisynthesis method of 17-hydroxyjolkinolide B. The semisynthesis method comprises the following steps: carrying out a cyclization reaction on a double bond at the C11 position of an epoxy ring of Jolkinolide A serving as a raw material; bromizing a methyl at the C17 position of a lactonic ring, then carrying out debromination and acetylation, and finally hydrolyzing an acetyl to obtain 17-hydroxyjolkinolide B. The invention discloses a new method for synthesizing 17-hydroxyjolkinolide B and provides a basis for research and development of jolkinolide type medicines. The successful synthesis of 17-hydroxyjolkinolide B provides a new direction for research of anti-cancer drugs. The method has the advantages that the yield of 17-hydroxyjolkinolide B can be improved, the production cost can be reduced, the market supply is enlarged and the cancer treatment cost is lowered.

Natural crag root of beijing euphorbia lactone Jolkinolide A and B synthetic method

The invention provides a method for synthesizing a jolkinolide A component and a jolkinolide B component which serve as main active components of a traditional Chinese medicine euphorbia fischeriana. The natural jolkinolide A and B is obtained by simple and high-efficiency synthesis through a series of chemical reactions by taking low-cost and readily-available p-13,19-dyhydroxyl kaurene; a preparation condition, a preparation process and important spectral structures and physical property data of all midbodies and target compounds are supplied.

Efficient Synthesis of Jolkinolides A and B from Steviol

Jolkinolides, isolated from Euphorbia fischeriana Steud, are naturally occurring tetracyclic ent-abietane diterpenes, some of which exhibit promising antitumor and other biological activity. An efficient strategy for the synthesis of jolkinolides A and B is described starting from readily available steviol in 10 and 11 steps with total yields of over 10%, respectively.

TOTAL SYNTHESIS OF (+/-)-JOLKINOLIDE A, B, AND E UTILIZING A NEW MILD ESTERIFICATION FOLLOWED BY INTRAMOLECULAR WITTIG-HORNER REACTION

Jolkinolide A, B, and E were efficiently synthesized from 9-methoxycarbonyl-4,4,10-trimethyl-Δ6-8-octalone 8 through Δ8(14)-podocalpen-13-one 12.A new synthetic method of γ-ylidenbutenolide consisting of mild esterification and the s

Total Synthesis of (+/-)-Jolkinolide A and B

The first efficient synthesis of jolkinolide A and B from the diosphenol (7) is reported; the new synthetic method described may find use in the preparations of 4-ylidene-2,3-substituted butenolides.