3791-76-2

Usage

InChI:InChI=1/C17H18O4/c1-20-13-10-15(19)17(16(11-13)21-2)14(18)9-8-12-6-4-3-5-7-12/h3-7,10-11,19H,8-9H2,1-2H3

Upstream product

• 1775-97-9 flavokawain B 
• 76672-84-9 3-benzyl-5,7-dimethoxychroman-4-one 
• 119-64-2 tetralin 
• 21392-57-4 Dimethyl-chrysin 
• 500-99-2 3,5-dimethoxyphenol 
• 645-59-0 dihydrocinnamonitrile 
• 108979-08-4 (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(4-bromophenyl)prop-2-en-1-one 
• 2174-64-3 5-methoxyresorcinol 
• 75291-74-6 pinostrobin 
• 186581-53-3 diazomethane 
• 76444-56-9 Uvangoletin 
• 102-93-2 3-phenylpropionamide 

Downstream Products

• 859085-70-4 3-benzyl-5,7-dimethoxy-2-methyl-chromen-4-one 
• 105245-60-1 2'-Hydroxy-4',6'-dimethoxy-α-hydroxymethyldihydrochalcone 
• 76672-84-9 3-benzyl-5,7-dimethoxychroman-4-one 
• 76672-83-8 4',6',4''',6'''-Tetramethoxy-2',2'''-bi(dihydrochalconyloxy)methane 
• 71972-62-8 3-Benzyl-5,7-dimethoxychromone 
• 21392-57-4 Dimethyl-chrysin 

Relevant academic research and scientific papers

Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors

In a continuing study for discovering urease inhibitors based on flavonoids, nineteen reductive derivatives of flavonoids were synthesized and evaluated against Helicobacter pylori urease. Analysis of structure-activity relationship disclosed that 4-deoxy analogues are more potent than other reductive products. Out of them, 4′,7,8-trihydroxyl-2-isoflavene (13) was found to be the most active with IC50 of 0.85 μM, being over 20-fold more potent than the commercial available urease inhibitor, acetohydroxamic acid (AHA). Kinetics study revealed that 13 is a competitive inhibitor of H. pylori urease with a Ki value of 0.641 μM, which is well matched with the results of molecular docking. Biological evaluation and mechanism study of 13 suggest that it is a good candidate for discovering novel anti-gastritis and anti-gastric ulcer agent.

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora

Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC50 values of 0.014 and 0.23 μM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC50 values of 4.04 and 2.32 μM, respectively.

Pd-C/ammonium formate: A selective catalyst for the hydrogenation of chalcones to dihydrochalcones

Pd-C/ammonium formate is a highly efficient catalyst for the selective hydrogenation of chalcones to dihydrochalcones (DHCs). The reaction proceeds under mild conditions and the Pd-C catalyst is recovered without loss of activity.

A simple and efficient conversion of chalcones to dihydrochalcones

The remarcable efficiency of catalytic transfer hydrogenation of chalcones to dihydrochalcones using cyclohexene-Pd/C and ammonium formate-Pd/C is demonstrated.The method is preparatively simple and useful.

Facile reduction of chalcones to dihydrochalcones with NaBH4/Ni2+ system

Chalcones have been found to undergo facile reduction on treatment with sodium borohydride-nickel chloride system in dioxan-methanol medium to afford dihydrochalcones.

Selective Reduction in 2'-Hydroxychalcones

The selective reduction of double bond in 2'-hydroxychalcones with sodium dithionite under phase transfer catalysed conditions is described.