75291-74-6

Upstream product

• 480-39-7 pinocembrin 
• 74-88-4 methyl iodide 
• 1036-72-2 5,7-dimethoxyflavone 
• 77-78-1 dimethyl sulfate 
• 1775-97-9 flavokawain B 
• 520-28-5 tectochrysine 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 10035-10-6 hydrogen bromide 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 60-29-7 diethyl ether 
• 186581-53-3 diazomethane 
• 18956-15-5 pinostrobin chalcone 

Downstream Products

• 520-28-5 tectochrysine 
• 1036-72-2 5,7-dimethoxyflavone 
• 35241-55-5 1-(2,6-dihydroxy-4-methoxy-phenyl)-3-phenyl-propan-1-one 
• 18956-15-5 pinostrobin chalcone 
• 3791-76-2 2’-hydroxy-4’,6’-dimethoxydihydrochalcone 
• 1220680-30-7 7-methoxy-5-(prop-2-enyloxy)flavanone 
• 1220680-32-9 5-hydroxy-7-methoxy-6-(prop-2-enyl)flavanone 
• 1220680-24-9 7-methoxy-5-(3-methylbut-2-enyloxy)flavanone 
• 1227479-72-2 (5-hydroxy-7-methoxyflavonone)oxime 

Relevant academic research and scientific papers

Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora

Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC50 values of 0.014 and 0.23 μM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC50 values of 4.04 and 2.32 μM, respectively.

Efficient one-pot synthesis of hydroxyflavanones by cyclization and O-demethylation of methoxychalcones

An efficient one-pot method for the synthesis of hydroxyflavanones is described. Methoxychalcones are treated with 36% HBr to afford cyclization and regioselective O-demethylation products (2a-i) while cyclization and complete O-demethylation products (3a

Variations in the chemical shift of the 5-hydroxyl proton of 7-o-prenylated flavanones

In 1H nmr examination of 6- or 8-prenylated flavanone 7-methyl and 7-prenyl ethers, the signals of hydrogen-bonded hydroxyl proton appeared in relatively narrow region. Relatively large solvent effect was observed on the signal of 6-prenylflavanone 7-methyl and 7-prenyl ethers.

THE OCCURRENCE OF FLAVANONES IN THE FARINOSE EXUDATE OF THE FERN ONYCHIUM SILICULOSUM

The yellow farina on fertile pinnules of Onychium siliculosum is composed of 2',6'-dihydroxy-4'-methoxychalcone and 2',6'-dihydroxy-4,5'-dimethoxychalcone.Heating of the crude extract brings about isomerization to pinostrobin and to 5-hydroxy-7,8-dimethoxyflavanone and 5-hydroxy-6,7-dimethoxyflavanone, respectively.The latter flavanone, recently reported as a constituent of this fern, is thus not a natural product. - Key Word Index: Onychium siliculosum; Pteridophyta; frond exudate; chalcone isomerization; 5-hydroxy-7,8-dimethoxyflavanone; 5-hydroxy-6,7-dimethoxyflavanone.