37919-93-0Relevant academic research and scientific papers
Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol
Mazzotta, Sarah,Berastegui-Cabrera, Judith,Vega-Holm, Margarita,García-Lozano, María del Rosario,Carretero-Ledesma, Marta,Aiello, Francesca,Vega-Pérez, José Manuel,Pachón, Jerónimo,Iglesias-Guerra, Fernando,Sánchez-Céspedes, Javier
, (2021/06/30)
Nowadays there is not an effective drug for the treatment of infections caused by human adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and immunosuppressed patients. Here, we describe the design, synthesis and biological evaluation as anti-adenovirus agents of a new library (57 compounds) of diester, monoester and triazole derivatives based on 3-amino-1,2-propanediol skeleton. Seven compounds (17, 20, 26, 34, 44, 60 and 66) were selected based on their high anti-HAdV activity at low micromolar concentration (IC50 from 2.47 to 5.75 μM) and low cytotoxicity (CC50 from 28.70 to >200 μM). In addition, our mechanistic assays revealed that compounds 20 and 44 might be targeting specifically the HAdV DNA replication process, and compound 66 would be targeting HAdV E1A mRNA transcription. For compounds 17, 20, 34 and 60, the mechanism of action seems to be associated with later steps after HAdV DNA replication.
Enzymatic Oxidative Conversion of Thio to Oxo by Baker's Yeast in Thiocarbamates and Thioureas
Kamal, Ahmed,Rao, Maddamsetty V.,Rao, Adari B.
, p. 655 - 656 (2007/10/02)
The enzymatic conversion of aryl allylthiocarbamates and 1-allyl-3-arylthioureas by baker's yeast to the corresponding carbamates and ureas in good yields is described.
