379255-56-8

Usage

Uses

Used in Pharmaceutical Industry:
(3-FLUORO-PHENOXY)-ACETIC ACID HYDRAZIDE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to inhibit the growth of cancer cells. It serves as a key component in developing new drugs for cancer therapy, potentially leading to more effective treatments.
Used in Agrochemical Industry:
(3-FLUORO-PHENOXY)-ACETIC ACID HYDRAZIDE is used as a building block in the creation of agrochemicals, specifically for its antibacterial and antifungal properties. This application helps in developing solutions to combat microbial infections in agriculture, thereby improving crop yields and food security.
Used in Cancer Therapy Research:
(3-FLUORO-PHENOXY)-ACETIC ACID HYDRAZIDE is used as a subject of research for its potential role in cancer therapy. Scientists are investigating its ability to inhibit cancer cell growth, with the aim of discovering new therapeutic agents and treatment strategies for various types of cancer.
Used in Antibacterial and Antifungal Applications:
(3-FLUORO-PHENOXY)-ACETIC ACID HYDRAZIDE is used as an active ingredient in the development of antibacterial and antifungal agents. Its properties make it a valuable component in creating new treatments for bacterial and fungal infections, contributing to the fight against antibiotic and antifungal resistance.

Upstream product

• 777-70-8 (3-fluoro-phenoxy)-acetic acid ethyl ester 
• 372-20-3 3-fluorophenol 

Downstream Products

• 299442-31-2 5-{[(3-fluorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-amine 

Relevant academic research and scientific papers

Synthesis and larvicidal activity of 1,3,4-oxadiazole derivatives containing a 3-chloropyridin-2-yl-1H-pyrazole scaffold

Abstract: A new series of 1,3,4-oxadiazole derivatives with a 3-chloropyridin-2-yl-1H-pyrazole moiety was designed, synthesized, and characterized. The results of bioassay against Helicoverpa armigera and Plutella xylostella indicated that some of the synthesized compounds showed remarkable larvicidal activity. In particular, the LC50 values of the most active compounds against P. xylostella were 46.5, 23.9, and 13.9?mg/dm3, and against Helicoverpa armigera were 88.3 and 69.5?mg/dm3, the latter being slightly better than commercial chlorpyrifos (LC50 103.77?mg/dm3). Preliminary SAR was also discussed. Graphical abstract: [Figure not available: see fulltext.].

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2- (phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives

An elevated level of blood uric acid (hyperuricemia) is the underlying cause of gout. Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. Allopurinol, a widely used xanthine oxidase inhibitor is the most commonly used drug to treat gout. However, a small but significant portion of the population suffers from adverse effects of allopurinol that includes gastrointestinal upset, skin rashes and hypersensitivity reactions. Moreover, an elevated level of uric acid is considered as an independent risk factor for cardiovascular diseases. Therefore use of allopurinol-like drugs with minimum side effects is the ideal drug of choice against gout. In this study, we report the synthesis of a series of pyrimidin-5-one analogues as effective and a new class of xanthine oxidase inhibitors. All the synthesized pyrimidin-5-one analogues are characterized by spectroscopic techniques and elemental analysis. Four (6a, 6b, 6d and 6f) out of 20 synthesized molecules in this class showed good inhibition against three different sources of xanthine oxidase, which were more potent than allopurinol based on their respective IC50 values. Molecular modeling and docking studies revealed that the molecule 6a has very good interactions with the Molybdenum-Oxygen-Sulfur (MOS) complex a key component in xanthine oxidase. These results highlight the identification of a new class of xanthine oxidase inhibitors that have potential to be more efficacious, than allopurinol, to treat gout and possibly against cardiovascular diseases.