379262-06-3

Upstream product

• 5983-09-5 2',3'-Dideoxyuridine 
• 98-88-4 benzoyl chloride 
• 6553-96-4 2,4,6-triisopropylphenylsulfonyl chloride 
• 28616-91-3 1-(5-O-benzoyl-2,3-dideoxy-β-D-glycero-pentofuranosyl)uracil 

Downstream Products

• 379262-08-5 benzoic acid 5-{4-[N'-(2-hydroxy-benzoyl)-hydrazino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis and antiviral evaluation of C-4-hydrazide derivatives of 2′,3′-dideoxycytidine

Syntheses of three hitherto unknown derivatives of 2′,3′-dideoxycytidine, namely C-4-(salicylic hydrazide)-ddC, C-4-(N-butyloxycarbonyl-isoleucine hydrazide)-ddC and its N-unprotected chlorhydrate salt have been carried out. These compounds do not induce inhibition of HIV-1 replication in cell culture experiments. Nevertheless, the modifications on the base moiety increased in all cases the lipophilicity of the parent molecule with an acceptable water solubility compared to ddC.