37931-54-7

Basic information

• Product Name: N-benzyl-4-fluoro-N-methylaniline
• Synonyms: N-benzyl-4-fluoro-N-methylaniline
• CAS NO: 37931-54-7
• Molecular Weight: 215.27
• Mol File: 37931-54-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-benzyl-4-fluoro-N-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-4-fluoro-N-methylaniline(37931-54-7)
• EPA Substance Registry System: N-benzyl-4-fluoro-N-methylaniline(37931-54-7)

Safety Data

• Hazardous Substances Data: 37931-54-7(Hazardous Substances Data)

Upstream product

• 352-33-0 1-Chloro-4-fluorobenzene 
• 103-67-3 benzyl-methyl-amine 
• 459-59-6 4-fluoro-N-methylaniline 
• 100-39-0 benzyl bromide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 100-44-7 benzyl chloride 

Relevant articles and documents

Synthesis of N-heterocyclic carbene-Pd(II) complexes and their catalytic activity in the Buchwald-Hartwig amination of aryl chlorides

Novel N-heterocyclic carbene-palladium(II) complexes using 2-picolinic acid as the ancillary ligand have been successfully developed under mild conditions. Their catalytic activity in organic synthesis has been initially tested in the Buchwald-Hartwig amination of secondary and primary amines with aryl chlorides. Various substituents on both substrates can be tolerated, giving the desired coupling products in good to almost quantitative yields. The minimum catalyst loading can be 0.01 mol%, implying their potential application toward industrial processes.

Regioselective, Photocatalytic α-Functionalization of Amines

Photocatalytic α-functionalization of amines provides a mild and atom-economical means to synthesize α-branched amines. Prior examples featured symmetrical or electronically biased substrates. Here we report a controllable α-functionalization of amines in which regioselectivity can be tuned with minor changes to the reaction conditions.

N-Heterocyclic carbene-palladacyclic complexes: synthesis, characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01 mol%).