37932-71-1

Usage

Uses

Used in Pharmaceutical Research and Development:
2,4-Imidazolidinedione, 5-(4-bromophenyl)-1-phenylis used as a building block in pharmaceutical research and development for its potential applications in creating new drugs and medications. Its unique chemical structure allows for the exploration of various therapeutic agents that can address a range of health conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 2,4-Imidazolidinedione, 5-(4-bromophenyl)-1-phenylis utilized as a key intermediate compound. It contributes to the synthesis of complex organic molecules, facilitating the development of novel chemical entities with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 5195-29-9 4-bromophenylglyoxal 
• 64-10-8 phenyl carbamate 
• 99-90-1 para-bromoacetophenone 

Relevant academic research and scientific papers

Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: Characterization of new CB 1 cannabinoid receptor inverse agonists/antagonists

Obesity and metabolic syndrome, along with drug dependence (nicotine, alcohol, opiates), are two of the major therapeutic applications for CB 1 cannabinoid receptor antagonists and inverse agonists. In the present study, we report the synthesis and structure-affinity relationships of 1,5-diphenylimidazolidine-2,4-dione and 1,3,5-triphenylimidazolidine-2,4-dione derivatives. These new 1,3,5-triphenylimidazolidine-2,4-dione derivatives and their thio isosteres were obtained by an original pathway and exhibited interesting affinity and selectivity for the human CB1 cannabinoid receptor. A [35S]-GTPγS binding assay revealed the inverse agonist properties of the compounds at the CB1 cannabinoid receptor. Furthermore, molecular modeling studies were conducted in order to delineate the binding mode of this series of derivatives into the CB1 cannabinoid receptor. 1,3-Bis(4-bromophenyl)-5-phenylimidazolidine-2,4-dione (25) and 1,3-bis(4-chlorophenyl)-5-phenylimidazolidine-2,4-dione (23) are the imidazolidine-2,4-dione derivatives possessing the highest affinity for the human CB1 cannabinoid receptor reported to date.

Microwave assisted synthesis of 1,5-disubstituted hydantoins and thiohydantoins in solvent-free conditions

1,5-Disubstituted hydantoins/thiohydantoins 3a-p have been synthesized in 81-95% yield by a microwave-promoted solvent-free condensation of arylglyoxals 1 and phenylurea/thiourea 2 using PPE as a reaction mediator. This method can be extended towards the parallel synthesis of 3. The workup is simple and involves treatment with ice-cold water.