37932-76-6Relevant academic research and scientific papers
Microwave assisted synthesis of 1,5-disubstituted hydantoins and thiohydantoins in solvent-free conditions
Paul,Gupta,Gupta,Loupy
, p. 75 - 78 (2002)
1,5-Disubstituted hydantoins/thiohydantoins 3a-p have been synthesized in 81-95% yield by a microwave-promoted solvent-free condensation of arylglyoxals 1 and phenylurea/thiourea 2 using PPE as a reaction mediator. This method can be extended towards the parallel synthesis of 3. The workup is simple and involves treatment with ice-cold water.
