37945-37-2

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE is used as a key intermediate in the synthesis of drugs for the treatment of certain medical conditions. Its unique chemical structure and properties make it a valuable component in the development of novel therapeutic agents.
In the synthesis of various drugs, ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE serves as a building block, contributing to the formation of the desired active pharmaceutical ingredients. Its presence in these compounds can enhance their efficacy, selectivity, and pharmacokinetic properties, ultimately leading to improved treatment outcomes for patients.
It is crucial to handle ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE with care and adhere to proper safety protocols when working with it in laboratory settings. This ensures the safety of researchers and the integrity of the experiments conducted using ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE.

Upstream product

• 108-94-1 cyclohexanone 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 10475-63-5 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester 
• 89649-25-2 3-Methyl-7a-pyrrolidin-1-yl-3a,4,5,6,7,7a-hexahydro-1H-indole-2-carboxylic acid ethyl ester 
• 98977-12-9 4-<5-(ethoxycarbonyl)-2-iodo-4-methylpyrrol-3-yl>-1-iodobutane 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 14369-88-1 (±)-ethyl 3-methyl-2H-azirine-2-carboxylate 
• 110569-93-2 4-(4-Methanesulfonyloxy-butyl)-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 6829-41-0 diethyl oximinomalonate 
• 874-23-7 2-acetylcyclohexanone 
• 6829-40-9 aminomalonic acid diethyl ester 
• 141-97-9 ethyl acetoacetate 
• 110569-81-8 3-(4-Chloro-butyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-ethyl ester 
• 110569-92-1 4-(4-Hydroxy-butyl)-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester 

Downstream Products

• 82635-55-0 1-(3-Benzyloxy-4-methyl-2-nitro-benzoyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid ethyl ester 
• 14006-85-0 3-Methyl-4,5,6,7-tetrahydro-1H-indole 

Relevant academic research and scientific papers

Porphyrins with Exocyclic Rings. 1. Chemistry of 4,5,6,7-Tetrahydro-1H-indoles: Synthesis of Acetoxy Derivatives, Dihydroindoles, and Novel Porphyrins with Four Exocyclic Rings

A variety of 4,5,6,7-tetrahydro-1H-indoles (THI's) and 4-oxo-4,5,6,7-tetrahydro-1-indoles (4-oxoTHI's) have been synthesized from cyclohexanone and 1,3-cyclohexanedione, respectively.The THI's reacted regioselectively with lead tetraacetate in acetic acid

Synthesis of Hydrocarbon-Strapped Porphyrins Containing Quinone and Phenolic Groups

A general synthesis of strapped porphyrins is described and is illustrated for porphyrins bearing quinone and phenol groups in the bridging strap, which is exclusively a polymethylene chain.The NMR and optical spectra of the strapped porphyrins are discussed.

Regioselectivity of Pyrrole Synthesis fromm Diethyl Aminomalonate and 1,3-Diketones: Further Observations

1,3-Diketones 1 react with diethyl aminomalonate (2) in boiling acetic acid to afford ethyl 2-pyrrolecarboxylates 6.Considerable regioselectivity was noted for the following classes of diketone: 2-acylcyclohexanones 10a,b , 2-acylcyclopentanones 10c,d pyrroles 13a,b>, 1-phenyl-2-alkyl-1,3-alkanediones 17a-d , 3-phenyl-2,4-hexanedione (21a) , 1-phenyl-3-alkyl-2,4-alkanediones 24a,b , and 2,2-dimethyl-3,5-alkanediones 29a,b .The yields varied with the structural class, decreasing with increased steric hindrance.The product structure correlated with the structure of the enolized diketones in the case of the 2-acylcycloalkanones studied.

The Synthesis and Chemistry of Azolenines. Part 2. A General Synthesis of Pyrrole-2-carboxylic Acid Derivatives by the Reaction of 2H-Azirines with Enamines, and the Crystal and Molecular Structure of Ethyl 3-Phenyl-4,5,6,7-tetrahydroindole-2-carboxylate

A new general synthesis of 1H-pyrrole-2-carboxylic acid derivatives is described.Reaction between appropriately substituted 2H-azirines and enamines gives a mixture of 2,3- and 3,4-dihydropyrroles, which on acid treatment yields the title compounds in mod