37945-37-2

Basic information

• Product Name: ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE
• Synonyms: ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE
• CAS NO: 37945-37-2
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.27
• Mol File: 37945-37-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE(37945-37-2)
• EPA Substance Registry System: ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE(37945-37-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 37945-37-2(Hazardous Substances Data)

Usage

General Description

ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE is a chemical compound with the molecular formula C15H19NO2. It is an ester derivative of indole carboxylic acid and is commonly used in the pharmaceutical industry for the synthesis of various drugs. ETHYL 3-METHYL-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLATE has potential pharmacological properties and is believed to have a role in the treatment of certain medical conditions. It is important to handle this chemical with caution and follow proper safety protocols when working with it in laboratory settings.

Upstream product

• 6829-40-9 aminomalonic acid diethyl ester 
• 874-23-7 2-acetylcyclohexanone 
• 6829-41-0 diethyl oximinomalonate 
• 14369-88-1 (±)-ethyl 3-methyl-2H-azirine-2-carboxylate 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 141-97-9 ethyl acetoacetate 
• 110569-81-8 3-(4-Chloro-butyl)-4-methyl-1H-pyrrole-2,5-dicarboxylic acid 5-ethyl ester 
• 110569-92-1 4-(4-Hydroxy-butyl)-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 98977-10-7 4-<5-(ethoxycarbonyl)-2-carboxy-4-methylpyrrol-3-yl>-1-iodobutane 
• 110569-93-2 4-(4-Methanesulfonyloxy-butyl)-3-methyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 98977-12-9 4-<5-(ethoxycarbonyl)-2-iodo-4-methylpyrrol-3-yl>-1-iodobutane 
• 108-94-1 cyclohexanone 
• 10475-63-5 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 

Downstream Products

• 14006-85-0 3-Methyl-4,5,6,7-tetrahydro-1H-indole 
• 82635-55-0 1-(3-Benzyloxy-4-methyl-2-nitro-benzoyl)-3-methyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

Porphyrins with Exocyclic Rings. 1. Chemistry of 4,5,6,7-Tetrahydro-1H-indoles: Synthesis of Acetoxy Derivatives, Dihydroindoles, and Novel Porphyrins with Four Exocyclic Rings

A variety of 4,5,6,7-tetrahydro-1H-indoles (THI's) and 4-oxo-4,5,6,7-tetrahydro-1-indoles (4-oxoTHI's) have been synthesized from cyclohexanone and 1,3-cyclohexanedione, respectively.The THI's reacted regioselectively with lead tetraacetate in acetic acid

Regioselectivity of Pyrrole Synthesis fromm Diethyl Aminomalonate and 1,3-Diketones: Further Observations

1,3-Diketones 1 react with diethyl aminomalonate (2) in boiling acetic acid to afford ethyl 2-pyrrolecarboxylates 6.Considerable regioselectivity was noted for the following classes of diketone: 2-acylcyclohexanones 10a,b , 2-acylcyclopentanones 10c,d pyrroles 13a,b>, 1-phenyl-2-alkyl-1,3-alkanediones 17a-d , 3-phenyl-2,4-hexanedione (21a) , 1-phenyl-3-alkyl-2,4-alkanediones 24a,b , and 2,2-dimethyl-3,5-alkanediones 29a,b .The yields varied with the structural class, decreasing with increased steric hindrance.The product structure correlated with the structure of the enolized diketones in the case of the 2-acylcycloalkanones studied.