379669-88-2

Upstream product

• 379669-82-6 3-phenyl-4-trifluoromethanesulfonyloxy-furan-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester 
• 379669-56-4 3-hydroxy-4-phenyl-furan-2,5-dicarboxylic acid 5-tert-butyl ester 2-methyl ester 
• 379669-84-8 3-phenyl-furan-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester 
• 379669-79-1 3-hydroxy-4-phenyl-furan-2,5-dicarboxylic acid dimethyl ester 
• 7040-23-5 dimethyl diglycolate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 

Downstream Products

• 67103-88-2 5-methyl-3-phenyl-furan-2-carboxylic acid 

Relevant academic research and scientific papers

A novel approach to the synthesis of 4-aryl-furan-3-ols

A novel, yet simple, method for the synthesis of 4-aryl-furan-3-ols is described. The condensation between dimethyl diglycolate 1 and various aryl glyoxylates 2 using KOt-Bu as base furnished a series of 4-aryl-furan-3-ols 4 bearing one tert-butyl ester and one methyl ester substituent. Such a mixed ester allowed easy differentiation of the two esters for selective chemical modification. In addition, these 4-aryl-furan-3-ols could be further transformed to other useful substituted furans through conversion to the triflates and subsequent metal-mediated reduction or coupling.