379669-79-1

Upstream product

• 67-56-1 methanol 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 7040-23-5 dimethyl diglycolate 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 379669-56-4 3-hydroxy-4-phenyl-furan-2,5-dicarboxylic acid 5-tert-butyl ester 2-methyl ester 
• 379669-82-6 3-phenyl-4-trifluoromethanesulfonyloxy-furan-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester 
• 379669-84-8 3-phenyl-furan-2,5-dicarboxylic acid 2-tert-butyl ester 5-methyl ester 
• 379669-86-0 5-hydroxymethyl-3-phenyl-furan-2-carboxylic acid tert-butyl ester 
• 379669-88-2 5-methyl-3-phenyl-furan-2-carboxylic acid tert-butyl ester 
• 67103-88-2 5-methyl-3-phenyl-furan-2-carboxylic acid 
• 915377-52-5 5-[7-(5-acetoxy-pentyl)-1H-indole-3-carbonyl]-4-methoxy-3-phenyl-furan-2-carboxylic acid methyl ester 
• 915377-49-0 5-[7-(5-acetoxypentyl)-1H-indole-3-carbonyl]-4-hydroxy-3-phenylfuran-2-carboxylic acid methyl ester 
• 915377-54-7 5-[7-(4-acetoxy-butyl)-1H-indole-3-carbonyl]-4-hydroxy-3-phenyl-furan-2-carboxylic acid methyl ester 
• 915377-51-4 5-[7-(4-acetoxy-butyl)-1H-indole-3-carbonyl]-4-methoxy-3-phenyl-furan-2-carboxylic acid methyl ester 
• 890120-41-9 5-[7-(3-acetoxy-propyl)-1H-indole-3-carbonyl]-4-hydroxy-3-phenyl-furan-2-carboxylic acid methyl ester 
• 890120-39-5 5-[7-(3-acetoxy-propyl)-1H-indole-3-carbonyl]-4-methoxy-3-phenyl-furan-2-carboxylic acid methyl ester 
• 915377-53-6 4-methoxy-5-[7-(2-methoxycarbonyl-ethyl)-1H-indole-3-carbonyl]-3-phenyl-furan-2-carboxylic acid methyl ester 
• 915377-55-8 4-hydroxy-5-[7-(2-methoxycarbonyl-ethyl)-1H-indole-3-carbonyl]-3-phenyl-furan-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

4-Hydroxyfuroic acid derivatives

This invention relates to treating diabetes mellitus with certain 4-hydroxyfuroic acid derivatives. These derivates are of formula (I) below. Each variable is defined in the specification.

Regioselective synthesis of 3-aryl-5-(1H-indole-3-carbonyl)-4-hydroxyfuroic acids as potential insulin receptor activators

3-Methoxy-4-aryl-furan-2,5-dicarboxylic acid (8) is selectively converted into its C-5 methylester (6) by treatment with methyl chloroformate followed by decarboxylation in one flask. Acylation of the resulting half ester with a 7-substituted indole was p

A novel approach to the synthesis of 4-aryl-furan-3-ols

A novel, yet simple, method for the synthesis of 4-aryl-furan-3-ols is described. The condensation between dimethyl diglycolate 1 and various aryl glyoxylates 2 using KOt-Bu as base furnished a series of 4-aryl-furan-3-ols 4 bearing one tert-butyl ester and one methyl ester substituent. Such a mixed ester allowed easy differentiation of the two esters for selective chemical modification. In addition, these 4-aryl-furan-3-ols could be further transformed to other useful substituted furans through conversion to the triflates and subsequent metal-mediated reduction or coupling.