37972-23-9

Basic information

• Product Name: 2-Chloro-4-trimethylsilanylethynyl-pyrimidine
• Synonyms: 2-Chloro-4-trimethylsilanylethynyl-pyrimidine;2-chloro-4-[2-(trimethylsilyl)ethynyl]Pyrimidine;2-Chloro-4-[trimethylsilylethynyl]pyrimidine
• CAS NO: 37972-23-9
• Molecular Formula: C₉H₁₁ClN₂Si
• Molecular Weight: 210.74
• Mol File: 37972-23-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-4-trimethylsilanylethynyl-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-trimethylsilanylethynyl-pyrimidine(37972-23-9)
• EPA Substance Registry System: 2-Chloro-4-trimethylsilanylethynyl-pyrimidine(37972-23-9)

Safety Data

• Hazardous Substances Data: 37972-23-9(Hazardous Substances Data)

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 37968-69-7 2-chloro-4-ethynylpyrimidine 
• 876521-36-7 1-(2-tert-butylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-ethane-1,2-dione 
• 876521-37-8 1-(2-iso-propylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-ethane-1,2-dione 
• 876521-23-2 2-tetr-butylamino-4-[(4-fluoro-phenyl)ethynyl]pyrimidine 
• 876521-35-6 2-iso-propylamino-4-[(4-fluorophenyl)ethynyl]pyrimidine 

Relevant articles and documents

An efficient route to 4-aryl-5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine

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Meridianins, marine alkaloids known as kinase inhibitors with an indole skeleton, and meridianin analogues were produced regioselectively and in moderate to good yields by thermal annulation of nitrosoarenes with 2-amino-4-ethynylpyrimidine and 2-chloro-4-ethynylpyrimidine, respectively, through a novel and atom-economical indolization process.

Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine

This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.