876521-23-2

Upstream product

• 876521-21-0 tert-butyl-(4-chloro-pyrimidin-2-yl)-amine 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 876521-32-3 2-tert-butylamino-4-ethynylpyrimidine 
• 352-34-1 4-fluoro-1-iodobenzene 
• 75-64-9 tert-butylamine 
• 570376-20-4 2-chloro-4-(4-fluoro-phenylethynyl)-pyrimidine 
• 37972-23-9 2-chloro-4-((trimethylsilyl)ethynyl)pyrimidine 
• 876521-29-8 2-tert-butylamino-4-(trimethylsilylethynyl)pyrimidine 

Downstream Products

• 456-22-4 4-Fluorobenzoic acid 
• 876521-36-7 1-(2-tert-butylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-ethane-1,2-dione 

Relevant academic research and scientific papers

Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine

This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.

An efficient route to 4-aryl-5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine

Starting from 2,4-dichloropyrimidine, a concise synthetic route to medicinally important 4-aryl-5-pyrimidinylimidazoles is described. Sequential substitution of the 4- and 2-chloro groups using a regioselective Sonogashira coupling, followed by nucleophil