37987-76-1

Upstream product

• 15307-86-5 [2-(2,6-dichloroanilino)phenyl]acetic acid 
• 658-78-6 1-nitro-4-trifluoroacetoxy-benzene 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 1264195-17-6 C₄₄H₇₀Cl₂N₃O₁₁P 
• 37984-23-9 diclofenac hydroxamic acid 

Relevant academic research and scientific papers

Synthesis of oligo(ethylene glycol) substituted phosphatidylcholines: Secretory PLA2-targeted precursors of NSAID prodrugs

A series of new phosphatidylcholine analogues with structurally modified sn-2-substituents have been prepared. The synthetic compounds include oligo(ethylene glycol) derivatives with chain-terminal pharmacophores that upon catalytic hydrolysis by phospholipase A2 yielded a series of oligo(ethylene glycol)-conjugates of the respective drugs. The approach here outlined may open a new way to employ OEG derivatives of phospholipids for therapeutic applications as secretory PLA2-targeted precursors of prodrugs.

Antiphlogistic phenylacetohydroxamic acid compositions

Phenylacetohydroxamic acids having the formula I STR1 wherein R1, R2, R3 and R4, independently of each other, represent hydrogen, chlorine, fluorine or bromine atoms or an alkyl or alkoxy group having at most 6 carbon atoms, and wherein R2 may additionally represent a trifluoromethyl group with the proviso that R1, R2 and R3 may not simultaneously represent hydrogen atoms and their pharmaceutically acceptable salts with bases, which compounds inhibit plateletaggregation and exhibit valuable pharmacological, in particular, antiphlogistic, analgesic and antipyretic activity.