38009-10-8Relevant academic research and scientific papers
Substituent Effects in Non-Aromatic Nitrogen Heterocycles: Alkaline Hydrolysis of Methyl N-Methyl(oxo)dihydropyridinecarboxylates and Diaza Analogues
Deady, Leslie W.
, p. 637 - 641 (2007/10/02)
Ester hydrolysis studies on some isomeric methoxycarbonyl derivatives of N-methylpyridin-2- and 4-ones show that reaction rates are affected by the relative positions of CO2Me, =O and NMe functions in ways which could not be predicted.However, from limited results for analogous pyrimidine derivatives, it seems that reactivity in these polyfunctional compounds can be predicted from the pyridine data by assuming additivity of effects.
