380152-24-9Relevant academic research and scientific papers
Synthesis, structural and spectroscopic characterization and biomimetic properties of new copper, manganese, zinc complexes: Identification of possible superoxide-dismutase mimics bearing hydroxyl radical generating/scavenging abilities
Lupidi, Giulio,Marchetti, Fabio,Masciocchi, Norberto,Reger, Daniel L.,Tabassum, Sartaj,Astolfi, Paola,Damiani, Elisabetta,Pettinari, Claudio
, p. 820 - 830 (2010)
A series of Cu(II), Zn(II) and Mn(II) coordination compounds has been synthesized by reaction of the corresponding metal salts and pyrazolyl-based ligands, i.e. the neutral 1-(2-(4-((2,2,2-tri(1H-pyrazol-1-yl)ethoxy)methyl)benzyloxy)-1,1-di(1H-pyrazol-1-yl)ethyl)-1H-pyrazole {p-C6H4[CH2OCH2C(pz)3]2, (L1), and the anionic hydridotris(3-phenyl-5-methylpyrazolyl)borate (L2)-, bis(pyrazolyl)acetate (L3) and bis(3,5-dimethylpyrazolyl)acetate (L4)-: the species [L1(CuCl2)2] (1), [L1(Cu(OAc)2)2] (2), [L1(Zn(OAc)2)2] (3), [(CuCl(L2)(HpzPh,Me)] (4), [Mn(L3)2]·2H2O, (5), [ZnCl(L3)(imH)]·MeOH [CuCl(L4)(imH)]·2H2O (7) have been obtained (HpzPh,Me=3-phenyl-5-methylpyrazole, imH=imidazole). Complexes 1 and 4 have been structurally characterized, also using less conventional powder diffraction methods. The superoxide scavenging activity has been characterized by indirect assays including EPR analysis. All complexes exhibit superoxide scavenging activity with IC50 in the μM range and they protect against the oxidative action of peroxynitrite in different ways. 1, 4 and 7 exert both an anti- and pro-oxidant effect depending on their concentration as evaluated by EPR and fluorescence methods. The pro-oxidative effects are absent in Zn(II) and Mn(II) complexes.
Structurally adaptive multitopic ligands containing tris(pyrazolyl)methane units as supramolecular synthons: Manganese carbonyl complexes
Reger, Daniel L.,Semeniuc, Radu F.,Smith, Mark D.
, p. 87 - 101 (2007/10/03)
The compounds {p-C6H4[CH2OCH2 C(pz)3]2- [Mn(CO)3]2} (OTf)2 (2, OTf- = CF3 SO3-), {m-C6H4 [CH2OCH2C(pz)3] 2[Mn(CO)3]2}(BF4)2 (3) and {1,2,4,5-C6H2[CH2OCH2 C-(pz)3]4[Mn(CO)3]4} (BF4)4 (4) have been prepared by reaction of the respective ligands with 'Mn (CO)5+,, prepared 'in situ' from the reaction of Mn(CO)5Br and AgBF4 or AgOTf in refluxing acetone. In the structures of all four complexes, the environment around the manganese atom is a slightly distorted octahedron, with the distortion caused by the restricted bite angle of the κ3-bonded tris(pyrazolyl)methane ligand. The structurally adaptive ligands in all four complexes support extended three-dimensional (3D) supramolecular structures. An important organizational feature for the three BF4- complexes is a double π-π and C-H?π interaction involving the pyrazolyl rings. The double π-π/-H?π interaction is intermolecular in 1 and 3 leading to the formation of chains and sheets. In the case of the tetratopic ligand in complex 4, the π-π/C-H?π interaction is intramolecular between adjacent (ortho) side arms. These supramolecular structures are also supported by weak C-H?F hydrogen bonds. For 3, classic π-π interactions of the central arene rings are also involved in organizing the 3D network. For 2, the structure is organized solely by C-H?O hydrogen bonding.
Self-assembly of a chiral three dimensional architecture composed of two different silver(I) helical chains connected by bitopic tris(pyrazolyl)methane ligands
Reger, Daniel L.,Semeniuc, Radu F.,Smith, Mark D.
, p. 543 - 546 (2007/10/03)
The coordination polymer {p-C6H4[CH2OCH2C (pz)3]2-Ag2 (BF4)2}n contains two opposite chirality metallohelicates, formed by a κ2, κsup
