3802-82-2

Usage

Type of compound

Fluorinated indole derivative

Industry use

Pharmaceutical industry

Purpose

Intermediate for the synthesis of various drugs

Chemical reactivity

Can undergo various chemical reactions to form new compounds with different pharmacological properties

Additional uses

Building block in the production of agrochemicals and other fine chemicals

Significance

Unique structure and reactivity make it valuable in the field of organic synthesis and drug discovery

Upstream product

• 394-28-5 2-Bromo-5-fluorobenzoic acid 
• 2713-69-1 2-(carboxymethyl-amino)-5-fluoro-benzoic acid 
• 2249-12-9 1-acetyl-5-fluoro-1H-indol-3-yl acetate 

Relevant academic research and scientific papers

Indoxyl-based umpolung strategy for the synthesis of unsymmetrical 3,3′-biindoles

3,3′-Bisindoles are known to be important structural motifs found in bioactive natural products, pharmaceuticals, and functional materials. Herein, a novel indoxyl-based approach was established for the synthesis of unsymmetrical 3,3′-biindoles from indoles and indoxyls. This approach generated moderate to excellent yields of the desired products (24 examples, up to 98% yield). The present method features broad substrate scope, operational simplicity, high atom economy, and utilization of non-toxic and inexpensive molecular iodine as catalyst. The applicability of this method has been demonstrated by the facile gram-scale synthesis.

Indole derivatives

The invention releates to indole derivatives of the formula STR1 wherein R 1 to R 4 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl or trifluoromethyl, R 5 and R 6 are, independently, hydrogen, halogen, lower-alkyl, cycloalkyl, trifluoromet