380243-07-2Relevant academic research and scientific papers
Asymmetric synthesis of β-amino-α-hydroxy acids through Lewis acid-mediated addition of ketene acetal to imines
Ha, Hyun-Joon,Ahn, Young-Gil,Woo, Jun-Sik,Lee, Gwan Sun,Lee, Won Koo
, p. 1667 - 1672 (2001)
Asymmetric synthesis of β-amino-α-hydroxy acids, key components of medicinally important molecules including Paclitaxel, KRI-1314, amastatin, and microginin, has been attained from the aldimine coupling of chiral imines N-alkylidene-(S)- or (R)-α-methylbenzylamine with (Z)-α-methoxyketene methyltrimethylsilyl acetal, followed by demethylation, hydrogenolysis, and hydrolysis.
