380243-10-7

Upstream product

• 380243-07-2 methyl (2S,3R)-2-methoxy-3-[(R)-α-methylbenzylamino]decanoate 
• 98-88-4 benzoyl chloride 

Relevant academic research and scientific papers

Asymmetric synthesis of β-amino-α-hydroxy acids through Lewis acid-mediated addition of ketene acetal to imines

Asymmetric synthesis of β-amino-α-hydroxy acids, key components of medicinally important molecules including Paclitaxel, KRI-1314, amastatin, and microginin, has been attained from the aldimine coupling of chiral imines N-alkylidene-(S)- or (R)-α-methylbenzylamine with (Z)-α-methoxyketene methyltrimethylsilyl acetal, followed by demethylation, hydrogenolysis, and hydrolysis.