3803-15-4Relevant academic research and scientific papers
SUBSTITUTED CYCLOHEXYL DERIVATIVES AS NK-3 RECEPTOR ANTAGONISTS
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Page/Page column 22, (2010/11/25)
The present invention relates to the compounds of formula (I): wherein A,B, n, X, Y, Z, R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them and their use in treating diseases mediated by neurokinin-3 (NK-3) receptors. These compounds can thus be used in methods of treatment to suppress and treat such disorders.
Aryl sulfones: A new class of γ-secretase inhibitors
Teall, Martin,Oakley, Paul,Harrison, Timothy,Shaw, Duncan,Kay, Euan,Elliott, Jason,Gerhard, Ute,Castro, Jose L.,Shearman, Mark,Ball, Richard G.,Tsou, Nancy N.
, p. 2685 - 2688 (2007/10/03)
The development of a novel series of 4-aryl, 4-phenylsulfonyl cyclohexananone-derived γ-secretase inhibitors for the potential treatment of Alzheimer's disease is described.
BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS
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Page 51, (2010/02/08)
Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.
