380383-75-5

Basic information

• Product Name: Hydrazinecarboxylic acid, 1-(4-methoxyphenyl)-, 1,1-dimethylethyl ester
• CAS NO: 380383-75-5
• Molecular Formula: C12H18N2O3
• Molecular Weight: 238.287
• Mol File: 380383-75-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Hydrazinecarboxylic acid, 1-(4-methoxyphenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboxylic acid, 1-(4-methoxyphenyl)-, 1,1-dimethylethyl ester(380383-75-5)
• EPA Substance Registry System: Hydrazinecarboxylic acid, 1-(4-methoxyphenyl)-, 1,1-dimethylethyl ester(380383-75-5)

Safety Data

• Hazardous Substances Data: 380383-75-5(Hazardous Substances Data)

Upstream product

• 870-46-2 t-butoxycarbonylhydrazine 
• 696-62-8 para-iodoanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 828-94-4 2,3-dimethyl-5-methoxyindole 
• 501-58-6 (E)-1,2-bis(4-methoxyphenyl)diazene 
• 13070-45-6 6-Methoxy-1,2,3,4-tetrahydrocarbazole 
• 18437-68-8 tert-butyl N-(4-methoxyphenyl)carbamate 

Relevant articles and documents

Biarylhydrazine compounds and their adducts and applications in the preparation of antitumor drugs

The present invention discloses a biarylhydrazine compound and its application in the preparation of antitumor drugs, the structure of the arylhydrazine compound as shown in formula I, the adduct is a biarylhydrazine compound on the hydrazine group plus benzyloxycarbonyl glycyl prolyl. The anticancer activity of the biarylhydrazine compounds of the present invention is superior to that of the existing positive control drug procarbazine; its Z-GP adduct can significantly reduce in vitro toxicity and in vivo toxicity to normal cells, and can be excised by FΑP-α enzyme specific hydrolysis in vivo (Z-GP) to release hydrolysate products; its Z-GP adduct can significantly inhibit tumor growth in tumor-bearing nude mice and reduce toxicity to non-target organs.

One-Pot Synthesis of Indoles and Pyrazoles via Pd-Catalyzed Couplings/Cyclizations Enabled by Aqueous Micellar Catalysis

An effective one-pot synthesis of either indoles or pyrazoles can be achieved via Pd-catalyzed aminations followed by subsequent cyclizations facilitated by aqueous micellar catalysis. This new technology includes efficient couplings with low loadings of palladium, a more stable source of the required hydrazine moiety, greater atom economy for the initial coupling, and reduced reaction temperatures, all leading to environmentally responsible processes.

Copper(I)-picolinic acid catalyzed N-arylation of hydrazides

An efficient copper-catalyzed carbon-nitrogen bond formation is described. The copper(I) complex with commercially available 2-picolinic acid ligand was found to be effective in N-arylation of N-Boc-hydrazine. This methodology offers a regioselective N-ar