380424-27-1

Basic information

• Product Name: 1-(2,3-difluoro-benzyl)-piperidine-4-carboxylic acid amide
• CAS NO: 380424-27-1
• Molecular Weight: 254.28
• Mol File: 380424-27-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,3-difluoro-benzyl)-piperidine-4-carboxylic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3-difluoro-benzyl)-piperidine-4-carboxylic acid amide(380424-27-1)
• EPA Substance Registry System: 1-(2,3-difluoro-benzyl)-piperidine-4-carboxylic acid amide(380424-27-1)

Safety Data

• Hazardous Substances Data: 380424-27-1(Hazardous Substances Data)

Upstream product

• 39546-32-2 4-carboxamidopiperidine 
• 446-57-1 1-(chloromethyl)-2,3-difluorobenzene 

Downstream Products

• 380426-23-3 2-chloro-6-[4-[1-(2,3-difluorobenzyl)]piperidinylamino]-9-cyclopentylpurine 
• 380424-77-1 4-amino-1-(2,3-difluorobenzyl)piperidine 

Relevant articles and documents

The design and synthesis of purine inhibitors of CDK2. III

Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.