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2,3-Difluorobenzyl chloride, with the chemical formula C7H5ClF2, is an organic compound that exists as a clear, colorless liquid. It is extensively utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals, serving as a benzyl protecting group in organic synthesis reactions and as a building block for the production of fluorinated compounds. Due to its high reactivity, it requires careful handling to prevent skin, eye irritation, and discomfort to the respiratory and digestive tracts. It is a key component in the creation of various important chemicals across different industries.

446-57-1

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446-57-1 Usage

Uses

Used in Pharmaceutical Industry:
2,3-Difluorobenzyl chloride is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines. Its role in the synthesis process is crucial for creating effective and safe medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-difluorobenzyl chloride is used as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its involvement in the synthesis of these chemicals helps to improve crop protection and yield.
Used in Organic Synthesis:
2,3-Difluorobenzyl chloride is used as a benzyl protecting group in organic synthesis reactions. This function is vital for the selective protection of certain functional groups during complex organic synthesis, allowing for the controlled formation of desired products.
Used in Fluorinated Compound Production:
As a building block for the production of fluorinated compounds, 2,3-difluorobenzyl chloride is instrumental in creating compounds with unique properties. These fluorinated compounds have applications in various fields, including materials science, chemical research, and specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 446-57-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 6 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 446-57:
(5*4)+(4*4)+(3*6)+(2*5)+(1*7)=71
71 % 10 = 1
So 446-57-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClF2/c8-4-5-2-1-3-6(9)7(5)10/h1-3H,4H2

446-57-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(Chloromethyl)-2,3-difluorobenzene

1.2 Other means of identification

Product number -
Other names 2,3-Difluorobenzyl Chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:446-57-1 SDS

446-57-1Relevant academic research and scientific papers

Dibenzo seven-membered ring derivative as well as preparation method and application thereof

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Paragraph 0072; 0093-0094; 0099-0108, (2021/03/31)

The invention relates to a dibenzo seven-membered ring derivative as well as a preparation method and application thereof. The chemical structure of the dibenzo seven-membered ring derivative is shownas a formula (I), and X1 and X2 are respectively and independently selected from H, F, Cl, Br or I. The preparation method has easily available raw materials, and can ensure continuous supply and production; the raw materials are cheap and have the cost advantage; and thiophenol or sodium thiophenol is not used, so that the method is more environment-friendly and is also beneficial to the body health of related personnel. 7,8-difluorodibenzo[b,e]thiazepine-11(6H)-one as one of the products can further react to obtain 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol, and the 7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-ol can be used as an important intermediate for preparing a drug baloxavir, so that baloxavir preparation cost is reduced.

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