380426-61-9

Basic information

• Product Name: 2-(2-FLUOROPHENOXY)ACETOHYDRAZIDE
• Synonyms: 2-(2-FLUOROPHENOXY)ACETOHYDRAZIDE;2-(2-fluorophenoxy)acetohydrazide(SALTDATA: FREE);2-(2-fluorophenoxy)ethanehydrazide;IVK/1269792;MLS000390079;Oprea1_235268;Oprea1_313356;SMR000259343
• CAS NO: 380426-61-9
• Molecular Formula: C₈H₉FN₂O₂
• Molecular Weight: 184.17
• Mol File: 380426-61-9.mol

Chemical Properties

• Boiling Point: 402.1°C at 760 mmHg
• Flash Point: 197°C
• Appearance: /
• Density: 1.281g/cm³
• Vapor Pressure: 1.12E-06mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 2-(2-FLUOROPHENOXY)ACETOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FLUOROPHENOXY)ACETOHYDRAZIDE(380426-61-9)
• EPA Substance Registry System: 2-(2-FLUOROPHENOXY)ACETOHYDRAZIDE(380426-61-9)

Safety Data

• Hazardous Substances Data: 380426-61-9(Hazardous Substances Data)

Usage

Acyl hydrazide derivative

It is a type of chemical compound that is derived from hydrazine, a compound with the formula N2H4, and an acyl group, which is a group of atoms that includes a carbonyl (C=O) bond.

Fluorophenoxy group

It is a group of atoms that includes a fluorine atom attached to a phenoxy ring (a ring structure that includes a benzene ring bonded to an oxygen atom).

Biological activities

These are the potential effects that the compound may have on living organisms, such as its ability to interact with proteins, enzymes, or other molecules in the body.

Therapeutic applications

These are the potential uses of the compound in the treatment of diseases or medical conditions.

Anti-inflammatory

This refers to the potential ability of the compound to reduce inflammation in the body.

Analgesic

This refers to the potential ability of the compound to relieve pain.

Drug discovery and development

This is the process of finding and developing new pharmaceutical compounds for the treatment of diseases or medical conditions.

InChI:InChI=1/C8H9FN2O2/c9-6-3-1-2-4-7(6)13-5-8(12)11-10/h1-4H,5,10H2,(H,11,12)

Upstream product

• 367-12-4 2-fluorophenol 
• 105-39-5 chloroacetic acid ethyl ester 
• 2248-56-8 ethyl 2-(4-fluorophenoxy)acetate 

Downstream Products

• 247128-21-8 5-{[(2-fluorophenyl)oxy]methyl}-1,3,4-thiadiazol-2-amine 
• 1263183-68-1 C₁₃H₁₀FN₃O₂S 
• 1052694-72-0 2-{[(2-fluorophenyl)oxy]acetyl}hydrazinecarbonylthioamide 

Relevant articles and documents

Synthesis, structure analysis, DFT calculations and energy frameworks of new coumarin appended oxadiazoles, to regress ascites malignancy by targeting VEGF mediated angiogenesis

Ascites malignancy is a frequent cause of morbidity and presents significant management problems which occur in many cancers. Angiogenesis plays a major role in the prognosis of ascites tumor through Vascular Endothelial Growth Factor (VEGF). Inhibition o

TRICYCLIC COMPOUNDS AND THEIR USE

Tricyclic compounds and their use are provided. More specifically, tricyclic compounds, pharmaceutical compositions containing them, methods for preparing them, and their use in therapy are also provided.

Synthesis and larvicidal activity of 1,3,4-oxadiazole derivatives containing a 3-chloropyridin-2-yl-1H-pyrazole scaffold

Abstract: A new series of 1,3,4-oxadiazole derivatives with a 3-chloropyridin-2-yl-1H-pyrazole moiety was designed, synthesized, and characterized. The results of bioassay against Helicoverpa armigera and Plutella xylostella indicated that some of the synthesized compounds showed remarkable larvicidal activity. In particular, the LC50 values of the most active compounds against P. xylostella were 46.5, 23.9, and 13.9?mg/dm3, and against Helicoverpa armigera were 88.3 and 69.5?mg/dm3, the latter being slightly better than commercial chlorpyrifos (LC50 103.77?mg/dm3). Preliminary SAR was also discussed. Graphical abstract: [Figure not available: see fulltext.].

Synthesis, Nematicidal Activity, and 3D-QSAR of Novel 1,3,4-Oxadiazole/ Thiadiazole Thioether Derivatives

Forty one novel 1,3,4-oxadiazole/thiadiazole thioether derivatives containing phenoxy moiety were designed and synthesized. Bioassay demonstrated that some of them showed remarkable activities against Tylenchulus semipenetrans in vitro and in vivo. Compounds 20, 21, 35 and 39 showed excellent lethal activities after treatment for 48?h in vitro, with LC50 values of 13.4?±?1.8, 11.7?±?2.5, 13.7?±?2.4 and 13.3?±?1.1?mg·L–1, respectively, which were obviously superior to fosthiazate (49.1?±?2.8?mg·L–1) and avermectin (26.6?±?2.3?mg·L–1). Compound 21 can effectively control the citrus nematode disease caused by T. semipenetrans at 200?mg·L–1 in vivo with (68?±?3)% inhibitory effect, which was even better than that of avermectin ((63?±?2)%). The CoMFA and CoMSIA models of three-dimensional quantitative structure-activity relationships (3D-QSARs) were established. The compound 33 was designed based on the 3D-QSAR models with more vigorous nematicidal activities in vitro (LC50?=?9.8?±?1.4?mg·L–1) and in vivo ((70?±?5)%). These results demonstrated that compound 33 can be considered as a potential nematicide.

2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives as well as preparation method and application thereof

The invention discloses 2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives as well as a preparation method and an application thereof. The 2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives have the general formula (I) shown in the following specification, wherein R1 represents as 4-chlorphenyl, 4-fluorophenyl, 4-methylphenyl, 4-methoxyphenyl, 4-nitrophenyl, 4-cyano-3,5-difluorophenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-t-butylphenyl, 2-fluorophenyl and other substituents; R2 represents methyl, ethyl, 4-chlorobenzyl, 2,4-dichlorobenzyl, 4-trifluoromethoxy, benzyl, 4-fluorobenzyl, 4-chlorobenzyl and other substituents; X represents O or S. The compound can be used as a pesticide for killing crop nematode and inhibiting bacterial diseases of crops.

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2- (phenoxymethyl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives

An elevated level of blood uric acid (hyperuricemia) is the underlying cause of gout. Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. Allopurinol, a widely used xanthine oxidase inhibitor is the most commonly used drug to treat gout. However, a small but significant portion of the population suffers from adverse effects of allopurinol that includes gastrointestinal upset, skin rashes and hypersensitivity reactions. Moreover, an elevated level of uric acid is considered as an independent risk factor for cardiovascular diseases. Therefore use of allopurinol-like drugs with minimum side effects is the ideal drug of choice against gout. In this study, we report the synthesis of a series of pyrimidin-5-one analogues as effective and a new class of xanthine oxidase inhibitors. All the synthesized pyrimidin-5-one analogues are characterized by spectroscopic techniques and elemental analysis. Four (6a, 6b, 6d and 6f) out of 20 synthesized molecules in this class showed good inhibition against three different sources of xanthine oxidase, which were more potent than allopurinol based on their respective IC50 values. Molecular modeling and docking studies revealed that the molecule 6a has very good interactions with the Molybdenum-Oxygen-Sulfur (MOS) complex a key component in xanthine oxidase. These results highlight the identification of a new class of xanthine oxidase inhibitors that have potential to be more efficacious, than allopurinol, to treat gout and possibly against cardiovascular diseases.