380451-93-4

Upstream product

• 98-91-9 thiobenzoic acid 
• 1440-61-5 N-chloroacetylmorpholine 

Downstream Products

• 389607-96-9 3-(cyclohex-3-en-1-yl)-1-phenyl-1-propanone 
• 5739-39-9 3-(4-chlorophenyl)-1-phenylpropan-1-one 
• 15289-04-0 1-phenyl-dec-5-yn-1-one 
• 96183-53-8 4,4-Dimethoxy-1-phenyl-1-butanone 
• 1669-49-4 3-(4-methoxyphenyl)-1-phenylpropan-1-one 
• 1674-38-0 dodecanophenone 
• 6303-82-8 1-phenylhexane-1,5-dione 
• 4535-64-2 5-methyl-1-phenylhex-4-en-1-one 
• 939-52-6 4-chloro-1-phenylbutan-1-one 
• 1533-20-6 1,3-diphenylbutane-1-one 

Relevant academic research and scientific papers

Copper-Mediated, Palladium-Catalyzed Coupling of Thiol Esters with Aliphatic Organoboron Reagents

Thiol esters and B-alkyl-9-BBN derivatives couple in the presence of a copper(I) carboxylate mediator and a palladium catalyst. In contrast to copper-mediated, palladium-catalyzed cross-couplings of thioorganics with boronic acids, the current coupling reaction of 9-BBN derivatives is facilitated by the addition of a base such as Cs2CO3. Under optimized conditions, a variety of thiol esters react with different B-alkyl-9-BBN derivatives giving ketones in moderate to excellent yields.