38047-06-2Relevant academic research and scientific papers
Synthesis, characterization and antibacterial activity of novel Schiff bases
Sreedhar, Pandiri,Srinivas, Gudipati,Raju, Rallabandi Madhusudan
, p. 1603 - 1606 (2016)
The present work describes the synthesis of novel Schiff bases (8.1-8.9) in five steps from diethyl oxalate and acetone as starting materials. Condensation of ethyl 1-(2-aminophenyl)-5-methyl-1H-pyrazole-3-carboxylate (6) with aromatic and heteroaromatic aldehydes (7.1-7.9) in presence of sodium sulphate at 50 °C in ethanol gave the corresponding imine derivatives (8.1-8.9) in quantitative yields. The structure of these compounds was determined by 1H NMR, mass and IR spectral data. These Schiff's bases were further evaluated for antibacterial activity against the selected Gram-positive and Gram-negative bacteria pathogens. The antibacterial activity data revealed that Schiff base embedded with heteroaromatic ring was found to exhibit good antibacterial activity than the aromatic ring.
